| Project/Area Number |
26890019
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor diagnostics
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| Research Institution | Tottori University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIKI TAKANORI 香川大学, 医学部, 教授 (30274294)
HOSAKA YOSHINAO 鳥取大学, 農学部, 教授 (00337023)
OHTA KEN-ICHI 香川大学, 医学部, 助教 (50403720)
SUZUKI SHINGO 香川大学, 医学部, 助教 (50451430)
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| Research Collaborator |
WARITA TOMOKO 徳島文理大学, 薬学部, 研究員 (00753112)
Oltvai Zoltan N. ピッツバーグ大学, 医学部, 准教授
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 薬効評価と予測 / がん細胞の特性 / 化学療法 / スタチン系薬剤 |
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| Outline of Final Research Achievements |
The anti-proliferative effect of stains on cancer cells has received widespread attention, since it has been reported that the statins may exhibit an anti-cancer effect in addition to their cholesterol-lowering effect. However, what type of cancer cell statin is effective for is unclear. Our previous study identified E-cadherin as a candidate factor determining the susceptibility to statin. To demonstrate that E-cadherin actually determines the susceptibility of cancer cells to statin, we examined if the regulation of E-cadherin expression has an influence on the susceptibility of cancer cells to statin in the present study. When E-cadherin gene (CDH1) was inserted into the statin-sensitive cells which had no E-cadherin, the half maximal inhibitory concentration (IC50) increased 3.7-fold. On the other hand, E-cadherin knockdown in the statin-resistant cancer cells increased their susceptibility to statin. These results strongly suggest that E-cadherin is a statin resistance factor.
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