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Analysis of molecular mechanisms involved in the susceptibility to statins on cancer cells

Research Project

Project/Area Number 26890019
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Tumor diagnostics
Research InstitutionTottori University

Principal Investigator

Warita Katsuhiko  鳥取大学, 農学部, 准教授 (40452669)

Co-Investigator(Renkei-kenkyūsha) MIKI TAKANORI  香川大学, 医学部, 教授 (30274294)
HOSAKA YOSHINAO  鳥取大学, 農学部, 教授 (00337023)
OHTA KEN-ICHI  香川大学, 医学部, 助教 (50403720)
SUZUKI SHINGO  香川大学, 医学部, 助教 (50451430)
Research Collaborator WARITA TOMOKO  徳島文理大学, 薬学部, 研究員 (00753112)
Oltvai Zoltan N.  ピッツバーグ大学, 医学部, 准教授
Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords薬効評価と予測 / がん細胞の特性 / 化学療法 / スタチン系薬剤
Outline of Final Research Achievements

The anti-proliferative effect of stains on cancer cells has received widespread attention, since it has been reported that the statins may exhibit an anti-cancer effect in addition to their cholesterol-lowering effect. However, what type of cancer cell statin is effective for is unclear. Our previous study identified E-cadherin as a candidate factor determining the susceptibility to statin. To demonstrate that E-cadherin actually determines the susceptibility of cancer cells to statin, we examined if the regulation of E-cadherin expression has an influence on the susceptibility of cancer cells to statin in the present study. When E-cadherin gene (CDH1) was inserted into the statin-sensitive cells which had no E-cadherin, the half maximal inhibitory concentration (IC50) increased 3.7-fold. On the other hand, E-cadherin knockdown in the statin-resistant cancer cells increased their susceptibility to statin. These results strongly suggest that E-cadherin is a statin resistance factor.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (5 results)

All 2015 2014 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Int'l Joint Research] ピッツバーグ大学医学部(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] ピッツバーグ大学医学部(米国)

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion2014

    • Author(s)
      K. Warita, T. Warita, C. Beckwitt, M. E. Schurdak, A. Vazquez, A. Wells, Z. N. Oltvai
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 7593-7593

    • DOI

      10.1038/srep07593

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 癌細胞のスタチン系薬剤感受性に関わる細胞特性に関する研究2015

    • Author(s)
      割田克彦,保坂善真,三觜友子,太田健一,鈴木辰吾,三木崇範,Zoltan N. Oltvai
    • Organizer
      日本解剖学会第70回中国・四国支部学術集会
    • Place of Presentation
      愛媛大学城北キャンパス(愛媛)
    • Year and Date
      2015-10-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] 癌細胞のスタチン系薬剤感受性を決定する因子に関する研究2015

    • Author(s)
      割田克彦,保坂善真,三觜友子,三木崇範,Zoltan N. Oltvai
    • Organizer
      第158回日本獣医学会学術集会
    • Place of Presentation
      北里大学獣医学部(青森)
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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