| Project/Area Number |
26890024
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Konan University |
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Principal Investigator |
KAWAUCHI KEIKO 甲南大学, 甲南大学フロンティアサイエンス学部, 講師 (40434138)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | がん / NF-kB / p53 / アクチン / ミトコンドリア / NF-ｋB / NF-κB / シグナル伝達 / Ras |
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| Outline of Final Research Achievements |
Actin cytoskeleton plays an important role in invasion, and metastasis of cancer cells. Accumulated evidence revealed that the tumor suppressor p53 prevents aggressiveness of cancer cells via remodeling of the actin cytoskeleton although the molecular mechanism has not been well studied. Since p53 is known to suppress NF-kB activity, we thought that NF-kB is involved in remodeling of the actin cytoskeleton modulated by dysfunction of p53. In this study, we showed that NF-kB prevented RAS-induced cleavage of b-actin through maintain mitochondria integrity, which might lead to invasion of cancer cells.
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