Molecular mechanism for evolution of metazoan multicellularity
Project/Area Number |
26891021
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Evolutionary biology
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Research Institution | Prefectural University of Hiroshima |
Principal Investigator |
Suga Hiroshi 県立広島大学, 生命環境学部, 准教授 (30734107)
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Project Period (FY) |
2014-08-29 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 多細胞性の進化 / 単細胞ホロゾア / 多細胞体制の進化 / 遺伝子導入 / カドヘリン / Notch / カプサスポラ / クレオリマックス / コラロキトリウム |
Outline of Final Research Achievements |
How did the multicellular system of animals evolve? Analysis of unicellular holozoans, the closest unicellular relatives of animals, is a key to solve this question. Surprisingly many “multicellularity genes”, which are in animals used for developing and maintaining multicellular bodies, have been found in the genomes of unicellular holozoans, suggesting that genes for cell adhesion, cell-cell communication, proliferation, extracellular matrix, and organ growth control were abundantly present already in premetazoans. In the project, we aimed to analyze these genes, taking advantage of the whole genome information of unicellular holozoans and the recently-developed method for transformation, in order to understand the molecular mechanisms for evolution of animal multicellularity.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] Possibility of RhoGDIβ as a molecular target for biomedical applications2016
Author(s)
Tatsuka, M., Fujiwara, M., Okamoto, M., Hori, M., Sugihara, Y., Jikihara, H., Nakaoji, K., Hamada, K., Suga, H., and Shimamoto, F.
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Journal Title
J Life Environ Sci
Volume: 8
Pages: 1-12
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Radiation-induced RhoGDIβ cleavage leads to perturbation of cell polarity: a possible link to cancer spreading2016
Author(s)
Fujiwara, M., Okamoto, M., Hori, M., Suga, H., Jikihara, H., Sugihara, Y., Shimamoto, F., Mori, T., Nakaoji, K., Hamada, K., Ota, T., Wiedemuth, R., Temme, A., and Tatsuka, M.
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Journal Title
J Cell Physiol
Volume: 0
Issue: 11
Pages: 0-0
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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