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Establishment of a rat transplant model of kidney with diabetic nephropathy into non-diabetic recipients and the reversibility of diabetic lesion

Research Project

Project/Area Number 26893003
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Urology
Research InstitutionHokkaido University

Principal Investigator

Iwami Daiki  北海道大学, 医学(系)研究科(研究院), 助教 (80581115)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords移植再生医療 / 糖尿病 / 免疫学 / 移植・再生医療
Outline of Final Research Achievements

We established a rat kidney transplant model in which immunosuppressive drugs are unnecessary to exclude the effect of the drugs on reversibility of diabetic lesion in the kidney. In that model, SDT rat as donor and SDT/SDJ F1 rat as recipient were used. SDT rat spontaneously develops diabetes mellitus and diabetes-associated complications such as cataract and diabetic nephropathy resulting in massive proteinuria and renal dysfunction. We also confirmed that SDT/SDJ F1 rat has normal glucose metabolism in oral glucose tolerance test. We underwent 4 cases of successful transplant of SDT kidney with diabetic nephropathy into non-diabetic SDT/SDJ F1 rat. Two recipients out of the 4 were evaluated at 2 weeks after transplant and the other 2 were evaluated at 24 weeks after transplant, however, no obvious amelioration or deterioration was observed pathologically. Our results suggest that reversibility of diabetic nephropathy need to be determined in longer observational period.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (8 results)

All 2015

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Lymph Node Stromal Fiber ER-TR7 Modulates CD4+ T Cell Lymph Node Trafficking and Transplant Tolerance2015

    • Author(s)
      Burell BE, Warren KJ, Nakayama Y, Iwami D, Brinkman CC, Bromberg JS
    • Journal Title

      Transplantation

      Volume: 99 Pages: 1119-1125

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vascular Endothelial Growth Factor C/Vascular Endothelial Growth Factor Receptor 3 Signaling Regulates Chemokine Gradients and Lymphocyte Migration from Tissues to Lymphatics2015

    • Author(s)
      Iwami D, Brinkman CC, Bromberg JS
    • Journal Title

      Transplantation

      Volume: 99 Pages: 668-677

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Intereukin-10 From Marginal Zone Precursor B-Cell Subset Is Required for Costimulatory Blockade-Induced Transplantation Tolerance2015

    • Author(s)
      Lal G, Nakayama Y, Sethi A, Singh AK, Burrell BE, Kulkarni N, Brinkman CC, Iwami D, Zhang T, Bromberg JS
    • Journal Title

      Transplantation

      Volume: 99 Pages: 1817-1828

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 一次移植後の下大静脈閉塞により二次脳死腎移植が機能しなかった先天性ネフローゼ症候群による小児腎不全症例2015

    • Author(s)
      森田研、樋口はるか、大石悠一郎、広瀬貴行、佐々木元、田邉起、堀田記世彦、岩見大基、篠原信雄
    • Journal Title

      日本小児腎不全学会雑誌

      Volume: 35 Pages: 188-192

    • Related Report
      2015 Annual Research Report
  • [Presentation] 当院における2型糖尿病を合併した腎移植症例の検討2015

    • Author(s)
      佐々木元、岩見大基、高田祐輔、樋口はるか、大石悠一郎、森田研、篠原信雄
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      ホテル日光熊本(熊本県熊本市)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] OGTTを用いた移植後耐糖能の変化とその影響因子の検討2015

    • Author(s)
      岩見大基、中村昭伸、森田研、高田祐輔、佐々木元、三好秀明、篠原信雄
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      ホテル日光熊本(熊本県熊本市)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 腎移植レシピエントのBMIによる移植後成績への影響.個別臓器WS-3腎移植の栄養学:新しい栄養指導法と自己管理教育の成果2015

    • Author(s)
      森田研、高田祐輔、佐々木元、岩見大基、篠原信雄
    • Organizer
      第51回日本移植学会総会
    • Place of Presentation
      ホテル日光熊本(熊本県熊本市)
    • Year and Date
      2015-10-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] Higher donor age is a significant predictor for TAC-induced nephrotoxicity in kidney allografts long term after transplant2015

    • Author(s)
      Daiki Iwami, Ken Morita, Hiromi Fujita, Yuichiro Oishi, Haruka Higuchi, Hajime Sasaki, Nobuo Shinohara
    • Organizer
      17th Congress of the European Society for Organ Transplantation
    • Place of Presentation
      The SQUARE meeting centre(Brussels, Belgium)
    • Year and Date
      2015-09-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-09-09   Modified: 2017-05-10  

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