Elucidation of the acquisiton mechanism of therapeutic resistance using imaging of genetic response to tumor hypoxia
| Project/Area Number |
26893005
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
TAKEUCHI YASUTO 北海道大学, 遺伝子病制御研究所, 博士研究員 (10735187)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 低酸素 / 悪性腫瘍 / レポーター遺伝子 / 治療抵抗性 / SPECT / PET / 核医学 / 分子イメージング / 動物モデル |
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| Outline of Final Research Achievements |
The aim of this study is to compare the tumor uptake level and tracer distribution of hypoxia-targeted PET tracers with those of gene activation levels by hypoxia-responsive elements (HRE). The tumor uptake level of hypoxia-targeted PET tracers reflected the gene activation level by HRE, which eventually conferred the resistance to anti-cancer therapies on the tumor cells and tracer distribution of 18F-FMISO PET might be more suitable than that of 64Cu-ATSM PET for planning hypoxia-targeted radiotherapy.
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Report
(3 results)
Research Products
(2 results)
