Role of epigenetic regulation by nuclear tyrosine kinases in hematologic malignancies
Project/Area Number |
26893036
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Hematology
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Research Institution | Chiba University |
Principal Investigator |
Aoyama Kazumasa 千葉大学, 医学(系)研究科(研究院), 特任研究員 (50734266)
|
Project Period (FY) |
2014-08-29 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | エピジェネティックス / 癌 / チロシンキナーゼ / ヒストン修飾 / 遺伝子発現 |
Outline of Final Research Achievements |
A constitutively active mutant of Abl tyrosine kinase causes chronic myelogenous leukemia (CML). In this study, we showed that Abl-mediated tyrosine phosphorylation leads to stabilization of histone deacetylase 1 accompanied by global histone deacetylations. Furthermore, we demonstrated that JAK2V617F, which is a constitutively active mutant of JAK2 tyrosine kinase and is found in patients with myeloproliferative neoplasms (MPN), cooperates with polycomb repressive complex2 in regulation of histone H3 lysine27 trimethylation. These results suggest that tyrosine kinases-regulated histone modifications plays an important role in CML and MPN.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Gene expression profiling of loss of TET2 and/or JAK2V617F mutant hematopoietic stem cells from mouse models of myeloproliferative neoplasms.2015
Author(s)
Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Hidaka T, Kubuki Y, Sashida G, Aoyama K, Yoshimitsu M, Abe H, Miike T, Iwakiri H, Tahara Y, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K
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Journal Title
Genom Data.
Volume: 4
Pages: 102-108
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Overexpression of Zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A.2015
Author(s)
Yuki, R., Aoyama, K., Kubota, S., Yamaguchi, N.-t., Kubota, S.-i., Hasegawa, H., Morii, M., Huang, X., Liu, K., Williams, R., Fukuda, M.N., and Yamaguchi, N.
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Journal Title
J. Cell. Biochem.
Volume: in press
Issue: 6
Pages: 954-968
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] c-Abl induces stabilization of histone deacetylase 1 (HDAC1) in a kinase activity-dependent manner.2015
Author(s)
Kazumasa Aoyama, Noritaka Yamaguchi, Ryuzaboro Yuki, Mariko Morii, Sho Kubota, Kensuke Hirata, Kohei Abe, Takuya Honda, Takahisa Kuga, Yuuki Hashimoto, Takeshi Tomonaga, and Naoto Yamaguchi
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Journal Title
Cell Biology International
Volume: 39
Issue: 4
Pages: 446-456
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Loss of TET2 has dual roles in murine myeloproliferative neoplasms: disease sustainer and disease accelerator.2015
Author(s)
Kameda T, Shide K, Yamaji T, Kamiunten A, Sekine M, Taniguchi Y, Hidaka T, Kubuki Y, Shimoda H, Marutsuka K, Sashida G, Aoyama K, Yoshimitsu M, Harada T, Abe H, Miike T, Iwakiri H, Tahara Y, Sueta M, Yamamoto S, Hasuike S, Nagata K, Iwama A, Kitanaka A, Shimoda K.
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Journal Title
Blood
Volume: 125
Issue: 2
Pages: 304-315
DOI
NAID
Related Report
Peer Reviewed / Open Access
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