| Project/Area Number |
26893053
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 強皮症 / 制御性B細胞 / 抗原特異性 / 動物モデル / 自己免疫疾患 / 全身性強皮症 / B細胞 / 膠原病 / 免疫 |
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| Outline of Final Research Achievements |
Immune cells play a crucial role in systemic sclerosis (SSc). B cells have more functions than producing antibodies. In addition, abnormal B cell function can drive the development of autoimmunity. However, specific B-cell subsets can also play a protective role during T cell-mediated inflammation and have been termed regulatory B cells. According to our previous studies, regulatory B cells can ameliorate autoimmune abnormalities in various diseases but the function of regulatory B cells has remained unclear in SSs. Therefore, we investigated the role of regulatory B cells, in the development of fibrosis and autoimmunity using the mouse models for SSc. In this study, we showed regulatory B cells are potent negative regulators of antigen-specific inflammation and T-cell-dependent autoimmunity in SSc model mice. This study may indicate first that regulatory B cells improved fibrosis and immunological abnormalities via an antigen-specific manner in SSc.
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