The role of regulatory B cells in systemic sclerosis
Project/Area Number |
26893053
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Dermatology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2014-08-29 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 強皮症 / 制御性B細胞 / 抗原特異性 / 動物モデル / 自己免疫疾患 / 全身性強皮症 / B細胞 / 膠原病 / 免疫 |
Outline of Final Research Achievements |
Immune cells play a crucial role in systemic sclerosis (SSc). B cells have more functions than producing antibodies. In addition, abnormal B cell function can drive the development of autoimmunity. However, specific B-cell subsets can also play a protective role during T cell-mediated inflammation and have been termed regulatory B cells. According to our previous studies, regulatory B cells can ameliorate autoimmune abnormalities in various diseases but the function of regulatory B cells has remained unclear in SSs. Therefore, we investigated the role of regulatory B cells, in the development of fibrosis and autoimmunity using the mouse models for SSc. In this study, we showed regulatory B cells are potent negative regulators of antigen-specific inflammation and T-cell-dependent autoimmunity in SSc model mice. This study may indicate first that regulatory B cells improved fibrosis and immunological abnormalities via an antigen-specific manner in SSc.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Multifaceted contribution of the TLR4-activated IRF5 transcription factor in systemic sclerosis.2016
Author(s)
Saigusa R, Asano Y, Taniguchi T, Yamashita T, Ichimura Y, Takahashi T, Toyama T, Yoshizaki A, Sugawara K, Tsuruta D, Taniguchi T, Sato S.
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Journal Title
Proc Natl Acad Sci USA.
Volume: 112
Issue: 49
Pages: 15136-41
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Nucleosome in patients with systemic sclerosis: possible association with immunological abnormalities via abnormal activation of T and B cells2015
Author(s)
Yoshizaki A, Taniguchi T, Saigusa R, Fukasawa T, Ebata S, Numajiri H, Nakamura K, Yamashita T, Takahashi T, Toyama T, Asano Y, Tedder TF, Sato S.
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Journal Title
Ann Rheum Dis.
Volume: N/A
Issue: 10
Pages: 1858-1865
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] 血管炎の新規治療2015
Author(s)
吉崎 歩
Organizer
第114回日本皮膚科学会総会
Place of Presentation
パシフィコ横浜
Year and Date
2015-05-29
Related Report
Invited
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[Presentation] Nucleosome, a basic repeating unit of chromatin, in patients with systemic sclerosis: Possible association with immunological abnormalities via anormal activation of T and B cells.2014
Author(s)
Yoshizaki A, Asano Y, Taniguchi T, Saigusa R, Nakamura K, Yamashita T, Takahashi T, Toyama T, Ichimura Y, Tamaki Z, Miyazaki M, Sato S.
Organizer
ACR/ARHP Annual Meeting
Place of Presentation
Boston Convention & Exhibition Center
Year and Date
2014-11-14 – 2014-11-19
Related Report
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