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Live imaging of effect of cytokines and oxidative stress on axonal transport of retinal ganglion cells.

Research Project

Project/Area Number 26893100
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionUniversity of Fukui

Principal Investigator

Seiji Miyake  福井大学, 医学部, 助教 (50572765)

Research Collaborator INATANI Masaru  福井大学, 医学部, 教授 (40335245)
TAKIHARA Yuji  福井大学, 医学部附属病院, 助教 (50640140)
YOKOTA Satoshi  京都大学, 医学研究科, 大学院生
Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords緑内障 / 網膜神経節細胞 / 軸索輸送 / 細胞小器官 / サイトカイン / 酸化ストレス / ミトコンドリア / 細胞死 / ライブイメージング
Outline of Final Research Achievements

The pathologies of glaucomatous optic neuropath are cell death of retinal ganglion cells (RGCs) and degeneration of their axons. Recently it is proposed that dysfunction of axonal transport was occurred before the RGC death. In fact, our group confirmed that dysfunction of axonal transport activity, which was induced by microtubule depolymerization and axotomy, is followed by cell death. However, relationship of cellular stresses and dynamics of axonal transport is unknown. In this study, effect of cytokines, which involves in glaucomatous neurodegeneration, and oxidative stress on axonal transport was evaluated in living RGCs.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (4 results)

All 2015

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 4 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] In vivo imaging of mitochondrial axonal transport in the diseased and aged mammalian CNS2015

    • Author(s)
      Takihara et al.
    • Journal Title

      Proceedings of the National Academy of Sciences of the U.S.A.

      Volume: 112 Issue: 33 Pages: 10515-10520

    • DOI

      10.1073/pnas.1509879112

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Altered Transport Velocity of Axonal Mitochondria in Retinal Ganglion Cells After Laser-Induced Axonal Injury In Vitro.2015

    • Author(s)
      Yokota S, Takihara Y, Arimura S, Miyake S, Takamura Y, Yoshimura N, Inatani M.
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 56 Issue: 13 Pages: 8019-8025

    • DOI

      10.1167/iovs.15-17876

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blue light-induced inflammatory marker expression in the retinal pigment epithelium-choroid of mice and the protective effect of a yellow intraocular lens material in vivo.2015

    • Author(s)
      Narimatsu T, Negishi K, Miyake S, Hirasawa M, Kurihara T, Tsubota K, Ozawa Y
    • Journal Title

      Experimental Eye Research.

      Volume: 132 Pages: 48-51

    • DOI

      10.1016/j.exer.2015.01.003

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Association of macular pigment optical density with serum concentration of oxidized low-density lipoprotein in healthy adults.2015

    • Author(s)
      Nagai N, Izumi-Nagai K, Suzuki M, Shinoda H, Koto T, Uchida A, Mochimaru H, Tomita Y, Miyake S, Kobayashi S, Sasaki M, Tsubota K, Ozawa Y.
    • Journal Title

      Retina

      Volume: 35(4) Issue: 4 Pages: 820-826

    • DOI

      10.1097/iae.0000000000000382

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2014-09-09   Modified: 2017-05-10  

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