| Project/Area Number |
26893109
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 膵癌 / TFF2 / 癌抑制遺伝子 / 膵癌抑制遺伝子 |
|---|
| Outline of Final Research Achievements |
Trefoil Family Factor 2 (TFF2) is a low-molecular weight protein which recently has been reported to have novel tumor suppressive function in gastric carcinogenesis. We found that pancreatic cancer develops in TFF2-deficient mouse with the activation of KRAS mutation, and that TFF2 can activate cancer suppressor gene SMAD4, indicating that TFF2 can act as tumor suppressor in pancreatic carcinogenesis. However, TFF2 protein cannot show tumor-suppressive effect when administered to cancer cells. We found that TFF2 must be expressed by cancer cells to suppress cancer proliferation, and that pioglitazone, a prescription drug to treat diabetes, is useful for this purpose.
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