Pathogenesis of early age-related macular degeneration using adaptive optics SLO

• Project/Area Number: 26893131
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: SOTARO OOTO 京都大学, 医学(系)研究科(研究院), 講師 (10511850)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 加齢黄斑変性 / 補償光学 / 視細胞 / 走査型レーザー検眼鏡 / 光干渉断層計 / ドルーゼン

Outline of Final Research Achievements

Adaptive optics scanning laser ophthalmoscopy revealed that cone density was decreased and cone arrangement was disrupted in eyes with early age-related macular degeneration, which was more remarkable in eyes with pseudodrusen. These results suggest that photoreceptors are damaged even in early stages of age-related macular degeneration, and photoreceptor damage may be involved in the progression to late age-related macular degeneration.

Research Products

• [Journal Article] Evaluation of photoreceptors in bietti crystalline dystrophy with CYP4V2 mutations using adaptive optics scanning laser ophthalmoscopy. (2015)
  • Author(s): Miyata M, Ooto S, Ogino K, Gotoh N, Morooka S, Makiyama Y, Hasegawa T, Sugahara M, Hata M, Yamashiro K, Yoshimura N
  • Journal Title: Am J Ophthalmol Volume: 161 Pages: 196-205
  • DOI: 10.1016/j.ajo.2015.10.018
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Pachychoroid neovasculopathy and age-related macular degeneration. (2015)
  • Author(s): Miyake M, Ooto S, Yamashiro K, Takahashi A, Yoshikawa M, Akagi-Kurashige Y, Ueda-Arakawa N, Oishi A, Nakanishi H, Tamura H, Tsujikawa A, Yoshimura N.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 16204-16204
  • DOI: 10.1038/srep16204
  • NAID: 120005758236
  • Peer Reviewed / Open Access
• [Journal Article] High-Resolution imaging of photoreceptors in macular microholes. (2014)
  • Author(s): Ooto S, Hangai M, Takayama K, Ueda-Arakawa N, Makiyama Y, Hanebuchi M, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 55 Pages: 5932-5943
  • Peer Reviewed
• [Presentation] ドルーゼンと加齢黄斑変性 (2015)
  • Author(s): 大音壮太郎
  • Organizer: 第26回宮城眼科先端医療研究会
  • Place of Presentation: 仙台
  • Year and Date: 2015-10-30
• [Presentation] ドルーゼンと加齢黄斑変性 (2015)
  • Author(s): 大音壮太郎
  • Organizer: 第73回埼玉眼科講習会
  • Place of Presentation: 川越
  • Year and Date: 2015-06-12
  • Invited
• [Presentation] AO-SLO (2015)
  • Author(s): 大音壮太郎
  • Organizer: 第4回日本視野学会学術集会
  • Place of Presentation: 金沢
  • Year and Date: 2015-05-30
• [Presentation] Adaptive Optics SLO (2015)
  • Author(s): 大音壮太郎
  • Organizer: 第119回日本眼科学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2015-04-17
• [Presentation] 補償光学と黄斑疾患 (2014)
  • Author(s): 大音壮太郎
  • Organizer: 群馬県眼科医会学術講演会
  • Place of Presentation: 前橋
  • Year and Date: 2014-10-24
  • Invited
• [Presentation] AO:OCTとの関係 (2014)
  • Author(s): 大音壮太郎
  • Organizer: 第62回日本臨床視覚電気生理学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-04
  • Invited
• [Book] 加齢黄斑変性 (2016)
  • Author(s): 大音壮太郎
  • Total Pages: 337
  • Publisher: 医学書院
• [Remarks] 眼底イメージング研究
  • URL: http://www.kuhp.kyoto-u.ac.jp/~ganka/html/kenkyu/kenkyu/imaging.htm