Pathogenesis of early age-related macular degeneration using adaptive optics SLO
Project/Area Number |
26893131
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
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Research Institution | Kyoto University |
Principal Investigator |
SOTARO OOTO 京都大学, 医学(系)研究科(研究院), 講師 (10511850)
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Project Period (FY) |
2014-08-29 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 加齢黄斑変性 / 補償光学 / 視細胞 / 走査型レーザー検眼鏡 / 光干渉断層計 / ドルーゼン |
Outline of Final Research Achievements |
Adaptive optics scanning laser ophthalmoscopy revealed that cone density was decreased and cone arrangement was disrupted in eyes with early age-related macular degeneration, which was more remarkable in eyes with pseudodrusen. These results suggest that photoreceptors are damaged even in early stages of age-related macular degeneration, and photoreceptor damage may be involved in the progression to late age-related macular degeneration.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Evaluation of photoreceptors in bietti crystalline dystrophy with CYP4V2 mutations using adaptive optics scanning laser ophthalmoscopy.2015
Author(s)
Miyata M, Ooto S, Ogino K, Gotoh N, Morooka S, Makiyama Y, Hasegawa T, Sugahara M, Hata M, Yamashiro K, Yoshimura N
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Journal Title
Am J Ophthalmol
Volume: 161
Pages: 196-205
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Pachychoroid neovasculopathy and age-related macular degeneration.2015
Author(s)
Miyake M, Ooto S, Yamashiro K, Takahashi A, Yoshikawa M, Akagi-Kurashige Y, Ueda-Arakawa N, Oishi A, Nakanishi H, Tamura H, Tsujikawa A, Yoshimura N.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 16204-16204
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] AO-SLO2015
Author(s)
大音壮太郎
Organizer
第4回日本視野学会学術集会
Place of Presentation
金沢
Year and Date
2015-05-30
Related Report
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