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Identification drosophila VNUT

Research Project

Project/Area Number 26893154
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Biological pharmacy
Research InstitutionOkayama University

Principal Investigator

Kato Yuri  岡山大学, 学内共同利用施設等, 助教 (10732042)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsATP / 小胞型ヌクレオチドトランスポーター / シグナル伝達 / 神経伝達 / 化学伝達
Outline of Final Research Achievements

ATP acts as a major chemical transmitter in purinergic chemical transmission, which is involved in a variety of neurological phenotypes such as sensory and pain perception. Vesicular nucleotide transporter (VNUT/SLC17A9) is responsible for vesicular storage and release of ATP in neuroendocrine cells. In this study, we identified drosophila VNUT and found a specific inhibitor of VNUT. VNUT-/- drosophila showed significant phenotypes.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (2 results)

All 2016

All Presentation (2 results)

  • [Presentation] 小胞型ヌクレオチドトランスポーター特異的阻害剤を用いたプリン作動性化学伝達のin vivo制御2016

    • Author(s)
      加藤百合
    • Organizer
      日本神経科学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-07-20
    • Related Report
      2015 Annual Research Report
  • [Presentation] 小胞型ヌクレオチドトランスポーター特異的阻害剤の同定とプリン作動性化学伝達のin vivo制御2016

    • Author(s)
      加藤百合
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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