Identification drosophila VNUT
| Project/Area Number |
26893154
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
Kato Yuri 岡山大学, 学内共同利用施設等, 助教 (10732042)
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ATP / 小胞型ヌクレオチドトランスポーター / シグナル伝達 / 神経伝達 / 化学伝達 |
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| Outline of Final Research Achievements |
ATP acts as a major chemical transmitter in purinergic chemical transmission, which is involved in a variety of neurological phenotypes such as sensory and pain perception. Vesicular nucleotide transporter (VNUT/SLC17A9) is responsible for vesicular storage and release of ATP in neuroendocrine cells. In this study, we identified drosophila VNUT and found a specific inhibitor of VNUT. VNUT-/- drosophila showed significant phenotypes.
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Report
(3 results)
Research Products
(2 results)
