Identification drosophila VNUT

Research Project

Project/Area Number	26893154
Research Category	Grant-in-Aid for Research Activity Start-up
Allocation Type	Single-year Grants
Research Field	Biological pharmacy
Research Institution	Okayama University
Principal Investigator	Kato Yuri 岡山大学, 学内共同利用施設等, 助教 (10732042)
Project Period (FY)	2014-08-29 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000) Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	ATP / 小胞型ヌクレオチドトランスポーター / シグナル伝達 / 神経伝達 / 化学伝達
Outline of Final Research Achievements	ATP acts as a major chemical transmitter in purinergic chemical transmission, which is involved in a variety of neurological phenotypes such as sensory and pain perception. Vesicular nucleotide transporter (VNUT/SLC17A9) is responsible for vesicular storage and release of ATP in neuroendocrine cells. In this study, we identified drosophila VNUT and found a specific inhibitor of VNUT. VNUT-/- drosophila showed significant phenotypes.