Construction of cartilage-bone tissue inducing hybrid biomaterial and Development of new articular cartilage reconstruction method
| Project/Area Number |
26893158
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2014-08-29 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ハニカムTCP / 軟骨組織形成 / 骨組織形成 / 硬組織形成微小環境 / 軟骨再生 / 骨再生 / BMP-2 / TGF-β |
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| Outline of Final Research Achievements |
In this study, we tried to develop the new biomaterial that induce cartilage and bone tissue seamless at the same time. When we induced cartilage tissue or bone tissue specifically by using different shape honeycomb TCP, honeycomb TCP containing through-hole with 75μm induced cartilage tissue formation. And on the other hand, honeycomb TCP containing through-hole with 300μm induced bone tissue formation.
Therefore we can induce cartilage tissue or bone tissue selectively by changing honeycomb TCP shape, and this finding indicates that the development of new articular cartilage reconstruction method reproduced articular cartilage tissue was suggested when we continue these TCP seamless.
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Report
(3 results)
Research Products
(6 results)
