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Construction of cartilage-bone tissue inducing hybrid biomaterial and Development of new articular cartilage reconstruction method

Research Project

Project/Area Number 26893158
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Surgical dentistry
Research InstitutionOkayama University

Principal Investigator

TAKABATAKE Kiyofumi  岡山大学, 医歯(薬)学総合研究科, 助教 (70736537)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
KeywordsハニカムTCP / 軟骨組織形成 / 骨組織形成 / 硬組織形成微小環境 / 軟骨再生 / 骨再生 / BMP-2 / TGF-β
Outline of Final Research Achievements

In this study, we tried to develop the new biomaterial that induce cartilage and bone tissue seamless at the same time. When we induced cartilage tissue or bone tissue specifically by using different shape honeycomb TCP, honeycomb TCP containing through-hole with 75μm induced cartilage tissue formation. And on the other hand, honeycomb TCP containing through-hole with 300μm induced bone tissue formation.
Therefore we can induce cartilage tissue or bone tissue selectively by changing honeycomb TCP shape, and this finding indicates that the development of new articular cartilage reconstruction method reproduced articular cartilage tissue was suggested when we continue these TCP seamless.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (6 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Effect of geometry and microstructure of honeycomb TCP scaffolds on bone regeneration.2014

    • Author(s)
      Takabatake kiyofumi
    • Journal Title

      Journal of Biomedical Material Research Part A

      Volume: 102 Pages: 2952-60

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] ハニカムβ-TCPを用いた骨・軟骨組織形成制御2015

    • Author(s)
      高畠清文、辻極秀次、于 淞、伊藤 聡、松田寛之、河合穂高、信長ひかり、中野敬介、長塚 仁
    • Organizer
      第36回岡山歯学会総会・学術大会
    • Place of Presentation
      岡山
    • Year and Date
      2015-09-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] ハニカムβ-TCPの孔径による硬組織再生制御2015

    • Author(s)
      于 淞、高畠清文、辻極秀次、伊藤 聡、松田寛之、信長ひかり、中野敬介、長塚 仁
    • Organizer
      第24回硬組織再生生物学会学術大会・総会
    • Place of Presentation
      大阪
    • Year and Date
      2015-08-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ハニカムTCPを用いた幾何学構造による骨・軟骨組織再生制御2015

    • Author(s)
      高畠 清文
    • Organizer
      第69回日本口腔科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] ハニカムβ-TCPを用いた幾何学構造による骨・軟骨組織再生制御2015

    • Author(s)
      高畠清文、辻極秀次、于 淞、武部祐一郎、伊藤 聡、藤井昌江、松田寛之、河合穂高、長塚 仁
    • Organizer
      第69回NPO法人日本口腔科学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] ハニカムβ-TCP を用いた細胞外微小環境再現による硬組織再生2014

    • Author(s)
      高畠 清文
    • Organizer
      第56回歯科基礎医学会学術大会・総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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