The role of THBS-1 expression in radioresistance

• Project/Area Number: 26893177
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: General surgery
• Research Institution: The University of Tokushima
• Principal Investigator: TAKASU Chie 徳島大学, 大学病院, 助教 (70582823)
• Project Period (FY): 2014-08-29 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: HDAC阻害剤 / 放射線増感作用 / ヒストン脱アセチル化酵素阻害剤 / 血管新生

Outline of Final Research Achievements

We　revealed that VEGF (Vascular endothelial growth factor), Beclin3 (autophagy-related gene) and caspase 3 (autophagy-related gene) played important role for enhancing
radiosensitivity by HDAC inhibitor.

Research Products

• [Journal Article] The Relationship of CD133, Histone Deacetylase 1 and Thrombospondin-1 in Gastric Cancer. (2015)
  • Author(s): Eto S, Yoshikawa ｋ, Shimada M, Higashijima J, Tokunaga T, Nakao T, Nishi M, Takasu C, Sato H, Kurita N.
  • Journal Title: Anticancer Res Volume: 35(4) Pages: 2071-2076
  • Peer Reviewed
• [Journal Article] The Relationship of CD133, Histone Deacetylase 1 and Thrombospondin-1 in Gastric Cancer. (2015)
  • Author(s): Eto S1, Yoshikawa K2, Shimada M1, Higashijima J1, Tokunaga T1, Nakao T1, Nishi M1, Takasu C1, Sato H1, Kurita N1.
  • Journal Title: Anticancer Res Volume: 35 Pages: 2071-2076
  • Peer Reviewed
• [Presentation] 大腸癌肝転移におけるThrombospondin-1(THBS1)発現の意義 (2015)
  • Author(s): 寺奥大貴、島田光生、居村暁、森根裕二、池本哲也、荒川悠佑、東島潤、岩橋衆一、齋藤裕、高須千絵、山田眞一郎、石川大地、吉川雅登
  • Organizer: 第115回日本外科学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-04-18
• [Presentation] 胃癌におけるPD-1,THBS1発現は再発と関係する (2015)
  • Author(s): 江藤祥平、島田光生、岩田貴、吉川幸造、東島潤、徳永卓哉、中尾寿宏、西正暁、高須千絵
  • Organizer: 第115回日本外科学会学術集会
  • Place of Presentation: 名古屋国際会議場(愛知県名古屋市)
  • Year and Date: 2015-04-18