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Elucidation of glial cell neurotrophic factor GDNF by the control mechanism for the inflammation that occurs in the pulp and bone

Research Project

Project/Area Number 26893244
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionKyushu Dental College

Principal Investigator

SAITO NORIKO  九州歯科大学, 歯学部, 助教 (40735099)

Project Period (FY) 2014-08-29 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords象牙芽細胞様細胞 / GDNF / 細胞生存 / 再生医学 / グリア細胞神経栄養因子 / グリア細胞神経栄養因子(GDNF) / 国際情報交換
Outline of Final Research Achievements

We report the effect of GDNF-secreting ECB device, which allows constitutive secretion of glial cell neurotrophic factor (GDNF). These devices were provided by NsGENE, which is our collaborative company. Our result of ELISA assay indicate that GDNF continued secreting it from those devices for 12 months, and it was revealed that we could maintain those devices. We found that maintenance medium that was derived from those devices raised cell viability of odontblast like cell (KN-3 cell) under 0.1% serum.
These data suggest that GDNF-secreting ECB device are available to maintain odontblast viability and proliferation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • Research Products

    (3 results)

All 2015

All Presentation (3 results)

  • [Presentation] カプセル化細胞から分泌されたGDNFの象牙芽細胞様細胞生存能及ぼす影響2015

    • Author(s)
      西藤法子,諸冨孝彦,鷲尾絢子, 平田-土屋志津,北村知昭
    • Organizer
      第37回 日本バイオマテリアル学会大会
    • Place of Presentation
      京都府 京都サルサ
    • Year and Date
      2015-11-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] カプセル化された細胞から分泌されるグリア細胞神経栄養因子の効果2015

    • Author(s)
      西藤法子,諸冨孝彦,鷲尾絢子, 平田-土屋志津,北村知昭
    • Organizer
      第13回 日本再生歯科医学会学術大会・総会
    • Place of Presentation
      新潟県 日本歯科大学松戸歯学部
    • Year and Date
      2015-08-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of GDNF-secreting Device on the Viability of Odontoblast-like Cells2015

    • Author(s)
      西藤法子,諸冨孝彦,鷲尾絢子,花田可緒理,平田-土屋志津,Wahlberg Lars,Emerich Dwaine,北村知昭
    • Organizer
      日本歯科保存学会 2015年度春季学術大会(第142回)
    • Place of Presentation
      福岡県北九州市 国際会議場
    • Year and Date
      2015-06-25
    • Related Report
      2015 Annual Research Report

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Published: 2014-09-09   Modified: 2017-05-10  

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