The construction of 3 dimensional intestinal tract and mucosa model and the basic examination using oligonucleotide medicine.
Project/Area Number |
26893307
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Research Category |
Grant-in-Aid for Research Activity Start-up
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Allocation Type | Single-year Grants |
Research Field |
Medical pharmacy
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Research Institution | Osaka Ohtani University |
Principal Investigator |
WATANABE Chie 大阪大谷大学, 薬学部, 助教 (30737747)
|
Project Period (FY) |
2014-08-29 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | 核酸製剤 / 腸管粘膜再構築モデル / DDS / 核酸 |
Outline of Final Research Achievements |
In this study, the basic model of 3 dimensional intestinal tract and mucosa was reconstituted in vitro using several biological materials. The model was also examined by the oligonucleotide medicine or materials which had different molecular sizes. This basic model was important for the substitutional assay system of animal experimental models which predict drug absorption and pharmacokinetics and for the precise analysis where in vivo analysis could not achieve.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Enteral siRNA delivery technique for therapeutic gene silencing in the liver via the lymphatic route2015
Author(s)
Masahiro Murakami, Kazutaka Nishina, Chie Watanabe, Kie Yoshida-Tanaka, Wenying Piao, Hiroya Kuwahara, Yuji Horikiri, Kanjiro Miyata, Nobuhiro Nishiyama, Kazunori Kataoka, Masayuki Yoshida, Hidehiro Mizusawa & Takanori Yokota
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Journal Title
Scientific Reports
Volume: 5
Issue: 1
Pages: 17035-17947
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Liver-specific delivery of a novel DNA/RNA heteroduplex oligonucleotide via enteral routes produced by the combination of alpha-tocopherol conjugation and permeation enhancers.2016
Author(s)
C. Watanabe, Y.Cheng, A. Watari, M.Kondoh, K. Yagi, Y. Matsumoto, K. Toh, K. Miyata, K. Kataoka, S. Obika, K.Yoshida-Tanaka, K. Nishina. T. Yokota, and M. Murakami
Organizer
Controlled Release Society Annual Meeting & Exposition
Place of Presentation
Washington State Convention Center (Seattle, Washington, USA)
Year and Date
2016-07-17
Related Report
Int'l Joint Research
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