| Project/Area Number |
59570402
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Nagasaki University |
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Principal Investigator |
TUSJI Yoshiro Nagasaki University School of Medicine, Professor., 医学部, 教授 (30039812)
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| Co-Investigator(Kenkyū-buntansha) |
YANAI Masanori Nagasaki University School of Medicine, Leeturer., 医学部, 講師 (90128231)
桝 忠道 長崎大学, 医学部, 助教授 (30136668)
YANAGI Tadamichi Nagasaki University School of Medicine, Assistant Professor.
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| Project Period (FY) |
1984 – 1986
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| Project Status |
Completed (Fiscal Year 1986)
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| Budget Amount *help |
¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1985: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1984: ¥800,000 (Direct Cost: ¥800,000)
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| Keywords | Hyper IgE / Staph. aureus / Recurrent infection / Specific IgE antiboty / アレルギー |
|---|
| Research Abstract |
In case of hyper IgE syndrome, T lymphocyte dysfunction causes decline of IL-2 production and response. It makes difficult to be formed the specific protection against Staph. aureua which causes recurrent Staph. aureus infections. Staph. aureus as a allergen stimulates the production of IgE antibody, and elevated levels of serum IgE is caused by defect of suppressor T lymphocyte function.
In conclusion, a defect of specific protection against Staph. aureus and a allergic reaction to Staph. aureus are the basic causes of this syndrome.
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