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Study of caudate stimulation on intractable epilepsy

Research Project

Project/Area Number 61480311
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNagasaki University

Principal Investigator

MORI Kazuo  Professor, Nagasaki University School of Medicine, 医学部, 教授 (50025540)

Co-Investigator(Kenkyū-buntansha) KAMINOGO Makio  Instructor, Nagasaki University School of Medicine, 医学部, 助手 (40145256)
ISHIZAKI Hiroaki  Instructor, Nagasaki University School of Medicine, 医学部, 助手 (60136679)
ONO Kenji  Associate Professor, Nagasaki University School of Medicine, 医学部, 助教授 (60112372)
BABA Hiroshi  Instructor, Nagasaki University School of Medicine, 医学部, 助手 (20133176)
河野 輝昭  長崎大学, 医学部, 講師 (70112373)
三宅 仁志  長崎大学, 医学部, 助手 (30175616)
Project Period (FY) 1986 – 1988
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥6,500,000 (Direct Cost: ¥6,500,000)
Fiscal Year 1988: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
Fiscal Year 1986: ¥3,500,000 (Direct Cost: ¥3,500,000)
KeywordsIntractable epilepsy / Premotor cortex / Caudate nucleus / Caudate stimulation / Motor cortex / キンドリング / in vivo dialysis / 実験てんかん / 皮質低頻度刺激 / ペニシリン焦点 / DA / DOPAC / GABA / 5-HT / 低頻度持続刺激 / feedback刺激
Research Abstract

Roles of the caudate nucleus in seizure developments from the motor or premotor cortical foci were studied in experimental models of epilepsy. In chronic rats, continuous electrical stimulation with 8-10 Hz to the premotor cortex induced electroclinical seizures which were divided into 4 stages. Electrocoagulation or microinjection of muscimol (GABA agonist) to the ipsilateral caudate nucleus increased a stimulus threshold necessary to induce each seizure stage. Seizure developments of the premotor cortical kindling in rats were significantly suppressed following the ipsilateral caudate lesion. On the other hand, numbers of interictal spikes induced by application of penicillin to the motor cortex in acute cats were significantly decreased under the feedback stimulation (10 Hz) to the ipsilateral caudate nucleus. However, feedback caudate mucate stimulation did not modify full-blown sustained paroxysms.
Electrophysiological studies suggest that striato-nigro-thalamic circuits are composed-of two successive inhibitory links (GABAergic). Also, there exist powerful caudate-thalamic inhibitory pathways. Observed inhibitory effect following lesion of, or muscimol injection to the caudate nucleus may be due to disruption of this caudate-nigral inhibitory loop in which nigro-thalamic inhibition becomes more powerful. Inhibitory effects of feedback stimulation to the caudate nucleus on interictal cortical spikes may results from the latter circuit. These findings suggest that a functions of the caudate nucleus might be changeable according to various states of seizure.
Our preliminary study with in vivo microdialysis showed that measurements of extracellular neurotransmitters in the caudate nucleus during various seizure stage may be worthwhile.

Report

(4 results)
  • 1989 Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • 1986 Annual Research Report

Research Products

(30 results)

All Other

All Publications (30 results)

  • [Publications] 森和夫: "てんかんの発生機序をめぐって-運動野焦点に対する実験ならびに臨床的考察-" Neurosurgeons. 5. 201-211 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroshi Baba: "Transcallosal respones (TCR) in the chronic photosensitive baboon preparation,Papio Papio. II.Effect of premotor cortical kindling." Electroenceph clin Neurophysiol. 67. 564-569 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroshi Baba: "Experimental study of the generalization of seizure discharges in a low-frequency cortical stimulation model in rat: Effects of lesion in the caudate nucleus." Appl.Neurophysiol.50. 286-287 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kenji Ono: "Facilitation of premotor cortical seizure development by intranigral muscimol." Brain Res.405. 183-186 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kenji Ono: "A role of the striatum in premotor cortical siezure development." Brain Res.435. 84-90 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kenji Ono: "Kindling 3(Wada,J.A.ed.)" Raven Press,New York, 15 (1986)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kazuo Mori: "Basic mechanism and surgical intervention of the motor cortical epileptogenesis." Neurosurgeons. 5. 201-211 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroshi Baba: "Transcallosal response (TCR) in the chronic photosensitive baboon preparation, Papio Papio. II.Effect of premotor cortical kindling." Electroenceph clin Neurophyol. 67. 564-569 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hiroshi Baba: "Experimental study of the generalization of seizure discharges in a low-frequency cortical stimulation model in rat: Effects of lesion in the caudate nucleus." Appl Neurophysiol. 50. 286-287 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kenji Ono: "Facilitation of premotor cortical seizure development by intranigral muscimol." Brain Res. 405. 183-186 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kenji Ono: "A role of the striatum in premotor cortical seizure development." Brain Res. 435. 84-90 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kenji Ono: Kindling 3 (Wada, J.A. ed.). Raven Press, New York, 139-153 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Kenji Ono.: Brain Research. 475. 182-186 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 馬場啓至: Medico. 19. 19-22 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 馬場啓至: 第27回日本定位脳手術研究会講演集. 1989.

    • Related Report
      1988 Annual Research Report
  • [Publications] 森和夫: 臨床脳波. 29. 517-521 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Iwayama,K.: Neurological Research. 9. 30-37 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Baba,H.: Japanese Journal of Psychiatry & Neurology. 41. 549-550 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Ono K.: Brain Research. 435. 84-90 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Baba,H.: Electroenceph.clin.Neurophysiol.67. 556-563 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Baba,H.: Electroenceph.clin.Neurophysiol.67. 564-569 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Baba,H.: Epilepsia. 28. 645-650 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Baba,H.: Applied Neurophysiology. 50. 286-287 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 馬場啓至: Medico. 19(3). 19-22 (1988)

    • Related Report
      1987 Annual Research Report
  • [Publications] Mori,Kazuo: Applied Neurophysiol.48. 347-350 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Iwayama,Kaoru: Neurological Research. 8. 157-163 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Baba,Hiroshi: Jap.J.Psychiat.& Neurol.40. 485-487 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 岩山馨: 医学のあゆみ. 139. 563 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] Baba,Hiroshi,ed.by J.A.Wada: "Kindling 3 Premotor(area 6)cortical kindling in primates:Senegalese baboon and Rhesus monkey." Raven Press, 447-469 (1986)

    • Related Report
      1986 Annual Research Report
  • [Publications] 森和夫: "Neurosurgeons 5 てんかんの発生機序をめぐって-運動野焦点に対する実験ならびに臨床的考察-" 日本脳神経外科コングレス, 201-211 (1986)

    • Related Report
      1986 Annual Research Report

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Published: 1987-03-30   Modified: 2016-04-21  

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