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1989 Fiscal Year Final Research Report Summary

Study of caudate stimulation on intractable epilepsy

Research Project

Project/Area Number 61480311
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionNagasaki University

Principal Investigator

MORI Kazuo  Professor, Nagasaki University School of Medicine, 医学部, 教授 (50025540)

Co-Investigator(Kenkyū-buntansha) KAMINOGO Makio  Instructor, Nagasaki University School of Medicine, 医学部, 助手 (40145256)
ISHIZAKI Hiroaki  Instructor, Nagasaki University School of Medicine, 医学部, 助手 (60136679)
ONO Kenji  Associate Professor, Nagasaki University School of Medicine, 医学部, 助教授 (60112372)
BABA Hiroshi  Instructor, Nagasaki University School of Medicine, 医学部, 助手 (20133176)
Project Period (FY) 1986 – 1988
KeywordsIntractable epilepsy / Premotor cortex / Caudate nucleus / Caudate stimulation / Motor cortex
Research Abstract

Roles of the caudate nucleus in seizure developments from the motor or premotor cortical foci were studied in experimental models of epilepsy. In chronic rats, continuous electrical stimulation with 8-10 Hz to the premotor cortex induced electroclinical seizures which were divided into 4 stages. Electrocoagulation or microinjection of muscimol (GABA agonist) to the ipsilateral caudate nucleus increased a stimulus threshold necessary to induce each seizure stage. Seizure developments of the premotor cortical kindling in rats were significantly suppressed following the ipsilateral caudate lesion. On the other hand, numbers of interictal spikes induced by application of penicillin to the motor cortex in acute cats were significantly decreased under the feedback stimulation (10 Hz) to the ipsilateral caudate nucleus. However, feedback caudate mucate stimulation did not modify full-blown sustained paroxysms.
Electrophysiological studies suggest that striato-nigro-thalamic circuits are composed-of two successive inhibitory links (GABAergic). Also, there exist powerful caudate-thalamic inhibitory pathways. Observed inhibitory effect following lesion of, or muscimol injection to the caudate nucleus may be due to disruption of this caudate-nigral inhibitory loop in which nigro-thalamic inhibition becomes more powerful. Inhibitory effects of feedback stimulation to the caudate nucleus on interictal cortical spikes may results from the latter circuit. These findings suggest that a functions of the caudate nucleus might be changeable according to various states of seizure.
Our preliminary study with in vivo microdialysis showed that measurements of extracellular neurotransmitters in the caudate nucleus during various seizure stage may be worthwhile.

Research Products

(12 results)

All Other

All Publications (12 results)

  • [Publications] 森和夫: "てんかんの発生機序をめぐって-運動野焦点に対する実験ならびに臨床的考察-" Neurosurgeons. 5. 201-211 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Baba: "Transcallosal respones (TCR) in the chronic photosensitive baboon preparation,Papio Papio. II.Effect of premotor cortical kindling." Electroenceph clin Neurophysiol. 67. 564-569 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Baba: "Experimental study of the generalization of seizure discharges in a low-frequency cortical stimulation model in rat: Effects of lesion in the caudate nucleus." Appl.Neurophysiol.50. 286-287 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenji Ono: "Facilitation of premotor cortical seizure development by intranigral muscimol." Brain Res.405. 183-186 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenji Ono: "A role of the striatum in premotor cortical siezure development." Brain Res.435. 84-90 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenji Ono: "Kindling 3(Wada,J.A.ed.)" Raven Press,New York, 15 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuo Mori: "Basic mechanism and surgical intervention of the motor cortical epileptogenesis." Neurosurgeons. 5. 201-211 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Baba: "Transcallosal response (TCR) in the chronic photosensitive baboon preparation, Papio Papio. II.Effect of premotor cortical kindling." Electroenceph clin Neurophyol. 67. 564-569 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Baba: "Experimental study of the generalization of seizure discharges in a low-frequency cortical stimulation model in rat: Effects of lesion in the caudate nucleus." Appl Neurophysiol. 50. 286-287 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenji Ono: "Facilitation of premotor cortical seizure development by intranigral muscimol." Brain Res. 405. 183-186 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenji Ono: "A role of the striatum in premotor cortical seizure development." Brain Res. 435. 84-90 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenji Ono: Kindling 3 (Wada, J.A. ed.). Raven Press, New York, 139-153 (1986)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-25  

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