| Project/Area Number |
62570407
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Tokyo Metropolitan Institute of Gerontology |
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Principal Investigator |
OHKAWA S 東京都老人総合研究所, 臨床病理部, 研究員 (30072995)
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| Co-Investigator(Kenkyū-buntansha) |
杉浦 昌也 東京都立広尾病院, 内科, 副院長 (80072883)
上田 慶二 東京都老人総合研究所, 臨床生理部, 研究員
渡辺 千鶴子 東京都老人総合研究所, 臨床病理部, 研究員
今井 保 東京都老人総合研究所, 臨床病理部, 研究員 (80072908)
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| Project Period (FY) |
1987 – 1989
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| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
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| Keywords | conduction disturbances / complete A-V block / left bundle branch block / right bundle branch block / His bundle elecrogram / conduction system / 完全左脚ブロック / 工度房室ブロック / 高度ないし完全房室ブロック / Narrow QRS群 / Wide QRS群 / 刺激伝導系の病理 |
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| Research Abstract |
Histopathologic studies of the conduction system were performed in cases with various kinds of the conduction disturbances in the aged. The following results were obtained:
(1)Chronic advanced or complete A-V block. 35 cases examined had corresponding lesions in the conduction system. In the narrow QRS group(n=17) with A-H block and/or H-H' block on the HBE marked lesions of the AV node were rare, but lesions of the His bundle including the branching portion were frequently found. In the wide QRS group(n=18) with H-V block on the HBE bilateral bundle branches were markedly involved.
(2)LBBB associated with 1st degree A-V block 12 cases with A-V block(Group I) did not show more severe lesions in the right bundle branches comparing with 21 cases without A-V block(Group II), but the moderate lesions in the penetrating His was more frequently found in Group I than in Group II.
(3)Relationship between the QRS morphology and the site of lesion of right bundle branches in cases with RBBB. 15 cases showing RBBB+LAD revealed frequent lesions in the 1st portion of RBB, while 6 with RBBB+NAD or 15 with RBBB+RAD were more frequently involved in the 2nd portion of RBB. As to the QRS morphology the type of rsR' was found in 16, followed by 9 of qR type, 8 of R type, but there was no intimate relationship between the QRS type of RBBB and the site of lesion in the RBB.
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