• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1989 Fiscal Year Final Research Report Summary

Histological studies of the cardiac conduction system in the aged cases with conduction disturbances(II)

Research Project

Project/Area Number 62570407
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Metropolitan Institute of Gerontology

Principal Investigator

OHKAWA S  東京都老人総合研究所, 臨床病理部, 研究員 (30072995)

Co-Investigator(Kenkyū-buntansha) 杉浦 昌也  東京都立広尾病院, 内科, 副院長
上田 慶二  東京都老人総合研究所, 臨床生理部, 研究員
渡辺 千鶴子  東京都老人総合研究所, 臨床病理部, 研究員
Project Period (FY) 1987 – 1989
Keywordsconduction disturbances / complete A-V block / left bundle branch block / right bundle branch block / His bundle elecrogram / conduction system
Research Abstract

Histopathologic studies of the conduction system were performed in cases with various kinds of the conduction disturbances in the aged. The following results were obtained:
(1)Chronic advanced or complete A-V block. 35 cases examined had corresponding lesions in the conduction system. In the narrow QRS group(n=17) with A-H block and/or H-H' block on the HBE marked lesions of the AV node were rare, but lesions of the His bundle including the branching portion were frequently found. In the wide QRS group(n=18) with H-V block on the HBE bilateral bundle branches were markedly involved.
(2)LBBB associated with 1st degree A-V block 12 cases with A-V block(Group I) did not show more severe lesions in the right bundle branches comparing with 21 cases without A-V block(Group II), but the moderate lesions in the penetrating His was more frequently found in Group I than in Group II.
(3)Relationship between the QRS morphology and the site of lesion of right bundle branches in cases with RBBB. 15 cases showing RBBB+LAD revealed frequent lesions in the 1st portion of RBB, while 6 with RBBB+NAD or 15 with RBBB+RAD were more frequently involved in the 2nd portion of RBB. As to the QRS morphology the type of rsR' was found in 16, followed by 9 of qR type, 8 of R type, but there was no intimate relationship between the QRS type of RBBB and the site of lesion in the RBB.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 大川真一郎,渡辺千鶴子,上田慶二,杉浦昌也: "慢性に経過した高度ないし完全房室ブロック例の病理" 心臓ペ-シング. 3. 327-333 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大川真一郎,杉浦昌也,〓井誠,ほか: "腱索断裂による僧帽弁閉鎖不全例の臨床病理学的検討" J.Cardiol. 17. 507-519 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 杉浦昌也,大川真一郎,渡辺千鶴子 ほか: "Wolff-Parkinson-White症候群の副伝導路に関する臨床病理学的研究" 心臓. 20. 805-812 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大川真一郎,藤寿尚子,渡辺千鶴子,上田慶二: "老年者ペ-スメ-カ-植込み例の生命予後と生活予後" 心臓ペ-シング. 5. 313-330 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohkawa,S.,Imai,T.,Kuboki,K.,Chida,K.,Watanabe,C.,Shimada,H.: "Stenoric lesions and length of the left main coronary artery in the aged" Jpn Heart J.30. 779-788 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohkawa,S.,Imai,T.,Ueda,K.,H.Shimada,Sugiura,M.: "Silent myocardial ischemia in the aged:A retrospective study from the evaluation of necropsy hearts" Jpn Cire J.53. 1414-1418 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上田慶二,大川真一郎: "洞不全症候群,早川弘一,比江嶋一晶編;臨床心臓電気生理学" 南江堂, P.63-90/413 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大川真一郎: "高齢者にみられる心不全の治療,杉本恒明編;Common Disease Series 12.心不全" 南江堂, P.155-160/289 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohkawa S et al: "Electrophysiologic and histologic correlations in chronic complete A-V block" Circulation 64(2);215-231, 1981.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohkawa S et al: "A histologic study of the conduction system in cases with chronic advanced or complete A-V block" Proceedings of the Internat Symp on Cardiac Arrhythmias Excerpta Med p68-71, 1986.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugiura M, Ohkawa S et al: "A clinicopathological study on 25 cases of complete left bundle branch block" Jpn Heart J 20(2):163-176, 1979.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohkawa S: "An electrocardiographic and histological correlation study on atrioventricular conduction disturbances in the aged" Tokyo J Med Sci 85(2/3):143-166, 1978.

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1993-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi