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Histological studies of the cardiac conduction system in the aged cases with conduction disturbances(II)

Research Project

Project/Area Number 62570407
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionTokyo Metropolitan Institute of Gerontology

Principal Investigator

OHKAWA S  東京都老人総合研究所, 臨床病理部, 研究員 (30072995)

Co-Investigator(Kenkyū-buntansha) 杉浦 昌也  東京都立広尾病院, 内科, 副院長 (80072883)
上田 慶二  東京都老人総合研究所, 臨床生理部, 研究員
渡辺 千鶴子  東京都老人総合研究所, 臨床病理部, 研究員
今井 保  東京都老人総合研究所, 臨床病理部, 研究員 (80072908)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 1989: ¥500,000 (Direct Cost: ¥500,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1987: ¥1,000,000 (Direct Cost: ¥1,000,000)
Keywordsconduction disturbances / complete A-V block / left bundle branch block / right bundle branch block / His bundle elecrogram / conduction system / 完全左脚ブロック / 工度房室ブロック / 高度ないし完全房室ブロック / Narrow QRS群 / Wide QRS群 / 刺激伝導系の病理
Research Abstract

Histopathologic studies of the conduction system were performed in cases with various kinds of the conduction disturbances in the aged. The following results were obtained:
(1)Chronic advanced or complete A-V block. 35 cases examined had corresponding lesions in the conduction system. In the narrow QRS group(n=17) with A-H block and/or H-H' block on the HBE marked lesions of the AV node were rare, but lesions of the His bundle including the branching portion were frequently found. In the wide QRS group(n=18) with H-V block on the HBE bilateral bundle branches were markedly involved.
(2)LBBB associated with 1st degree A-V block 12 cases with A-V block(Group I) did not show more severe lesions in the right bundle branches comparing with 21 cases without A-V block(Group II), but the moderate lesions in the penetrating His was more frequently found in Group I than in Group II.
(3)Relationship between the QRS morphology and the site of lesion of right bundle branches in cases with RBBB. 15 cases showing RBBB+LAD revealed frequent lesions in the 1st portion of RBB, while 6 with RBBB+NAD or 15 with RBBB+RAD were more frequently involved in the 2nd portion of RBB. As to the QRS morphology the type of rsR' was found in 16, followed by 9 of qR type, 8 of R type, but there was no intimate relationship between the QRS type of RBBB and the site of lesion in the RBB.

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (36 results)

All Other

All Publications (36 results)

  • [Publications] 大川真一郎,渡辺千鶴子,上田慶二,杉浦昌也: "慢性に経過した高度ないし完全房室ブロック例の病理" 心臓ペ-シング. 3. 327-333 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大川真一郎,杉浦昌也,〓井誠,ほか: "腱索断裂による僧帽弁閉鎖不全例の臨床病理学的検討" J.Cardiol. 17. 507-519 (1987)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 杉浦昌也,大川真一郎,渡辺千鶴子 ほか: "Wolff-Parkinson-White症候群の副伝導路に関する臨床病理学的研究" 心臓. 20. 805-812 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大川真一郎,藤寿尚子,渡辺千鶴子,上田慶二: "老年者ペ-スメ-カ-植込み例の生命予後と生活予後" 心臓ペ-シング. 5. 313-330 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohkawa,S.,Imai,T.,Kuboki,K.,Chida,K.,Watanabe,C.,Shimada,H.: "Stenoric lesions and length of the left main coronary artery in the aged" Jpn Heart J.30. 779-788 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohkawa,S.,Imai,T.,Ueda,K.,H.Shimada,Sugiura,M.: "Silent myocardial ischemia in the aged:A retrospective study from the evaluation of necropsy hearts" Jpn Cire J.53. 1414-1418 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 上田慶二,大川真一郎: "洞不全症候群,早川弘一,比江嶋一晶編;臨床心臓電気生理学" 南江堂, P.63-90/413 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大川真一郎: "高齢者にみられる心不全の治療,杉本恒明編;Common Disease Series 12.心不全" 南江堂, P.155-160/289 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohkawa S et al: "Electrophysiologic and histologic correlations in chronic complete A-V block" Circulation 64(2);215-231, 1981.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohkawa S et al: "A histologic study of the conduction system in cases with chronic advanced or complete A-V block" Proceedings of the Internat Symp on Cardiac Arrhythmias Excerpta Med p68-71, 1986.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Sugiura M, Ohkawa S et al: "A clinicopathological study on 25 cases of complete left bundle branch block" Jpn Heart J 20(2):163-176, 1979.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ohkawa S: "An electrocardiographic and histological correlation study on atrioventricular conduction disturbances in the aged" Tokyo J Med Sci 85(2/3):143-166, 1978.

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 大川真一郎: "老年者の先天性心疾患" 治療. 71. 761-767 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川真一郎,藤森尚子,渡辺千鶴子,上田慶二: "老年者ペ-スメ-カ-植込み例の生命予後と生活予後" 心臓ペ-シング. 5. 90-96 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川真一郎: "老人の臓器の特徴ーその形態と機能ー心臓" 病理と臨床. 7. 1352-1355 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川真一郎: "高齢者弁膜症患の特徴" 進歩する心臓研究. 9. 11-21 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ohkawa S,Imai T,Kuboki K,Chida K,Watanabe C,Shimada H.: "Stenotic Lesions and Leugth of the left main coonay actery in the aged." Jpn Heart J. 30. 779-788 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Ohkawa S,Imai T,Ueda K,H shimada H,Sugiura M: "Silent myocaidial ischemia in the aged:A retrospective study from the evaluation of necropry hearts." Jpn Circ J. 53. 1414-1418 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川真一郎: "老人の無症候性虚血性心疾患,細田瑳一,岸田浩編:無症候性虚血性心疾患と心筋虚血Silent Myoc.Ischeura" 羊土社, P.109-116/159 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 大川真一郎: "高齢者にみられる心不全の治療,杉本恒明編:Common Disease Series 12.心不全" 南江堂, P.155-160/289 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] Kanemaru,K;Ohkawa,S.et al: Jpn J Med. 27. 74-78 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] Suzuki,Y;Fujimori,s;Sakai,M;Ohkawa,S;Ueda,K.: PACE. 11. 326-330 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大川真一郎、杉浦昌也 他: J Cardisl. 17. 507-519 (1987)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大川真一郎: 循環器科. 23. 267-278 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大川真一郎、今井保、杉浦昌也: Therap Res. 8. 1213-1218 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 杉浦昌也、大川真一郎 他: 心臓. 20. 805-812 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 早川弘一、比江嶋一昌 編、上田慶二、大川真一郎: "臨床心臓電気生理学" 南江堂, 1-413 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 太田邦夫監修、大川真一郎: "老化指標データブック" 朝倉書店, 1-334 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 大川真一郎,渡辺千鶴子,上田慶二,杉浦昌也: 心臓ペーシング. 3. 327-333 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Chidak,Sugiura M, OhkawaS, et al.: Japanese Heart Journal. 28. 307-321 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Ohkawa S, Watanabe C, Ueda K, Toka A, Sugiura M: Proceedings of the Intunational Sypuposium on Cardiac Arrby thuies. 68-71 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 大川真一郎,蔵本築: 臨床と研究. 64. 3119-3123 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 大川 真一郎: Therapeutic Research. 7. 922-924 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] Ezaki H, Ohkawa S, Miyagawa A, Ueda K, Sugiceva M: Japanese Heart Journal. 28. 933-940 (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 大川 真一郎: "図説 臨床看護医学 第13巻 「不整脈」" 同朋舎(福島保喜編), 355(158-163) (1987)

    • Related Report
      1987 Annual Research Report
  • [Publications] 上田慶二,大川真一郎: "臨床心臓電気生理学「洞不全症候群」" 南江堂(早川弘一,比江嶋-昌編), 413(63-90) (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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