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EXPERIMENTAL STUDY ON EFFECTS OF TPN FOR PREVENTION OF STRESS ULCER OCCURRENCE

Research Project

Project/Area Number 62570618
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionJikei University School of Medicine

Principal Investigator

KUBO Hirotaka  Lecturer, The Second Department of Surgery, The Jikei University School of Medicine., 第二外科, 講師 (70119791)

Co-Investigator(Kenkyū-buntansha) HORI Noriya  -ditto-, 第二外科, 助手 (20199524)
YOSHII Shuji  The Second Department of Surgery, The Jikei University School of Medicine., 第二外科, 助手 (50200928)
柏崎 修  東京慈恵会医科大学, 第二外科教室, 教授 (20056518)
Project Period (FY) 1987 – 1989
Project Status Completed (Fiscal Year 1989)
Budget Amount *help
¥2,400,000 (Direct Cost: ¥2,400,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥800,000 (Direct Cost: ¥800,000)
Fiscal Year 1987: ¥1,200,000 (Direct Cost: ¥1,200,000)
KeywordsSTRESS ULCER / TPN ADMINISTRATION / GASTRIC MUCOSAL MUCOIDS / HEXIOSAMINE / PURUIC METABOLISM / URIC ACID / GENERATIVE CELL ZONE IN GASTRIC MUMOSA / DEFENSIVE MUCAS-MUCOSAL BARRIER / フリ-ラジカル / 粘膜下血流 / 1.高カロリー輸液 / 2.ストレス潰瘍 / 3.胃粘膜ムコ物質 / 4.ヘキソサミン / 5.胃粘膜増殖細胞帯 / 6.胃粘膜ー粘液関門
Research Abstract

Through clinical experiment, it is known that formation of stress ulcer is prevented by supplying sufficient calories and amino acid under the TPN administration. However, the mechanism how the TPN treatment prevents the gastric mucosa from stress ulcer formation has not been understood.
[Experiment] The experiment was carried out on adult male Wister rats. Their weight ranged 200 to 250g. A silicon catheter was inserted into the superior vena cava via the external jugular vein to infuse TPN solution intravenously. Each of the rats was fed 250kcal/kg/day. To induce stress ulcers, the water-immersion method was taken. The rats were divided into two groups. One group was fed TPN. The other group was not fed TPN. All the rats were loaded with water immersion restraint for 1, 3, 5 or 8 hours. At the end of the experiment, the following levels were measured: 1. Ulcer index 2. Histological observation 3. Hexiosamine level in gastric mucosa and mucos 4. Serum gastrin and pepsinogen levels 5. U … More ric acid and water levels in the tissue to see effects on the gastric tissue pruic metabolism * The tissue uric acid level was measure by HPLC-ECD.
[Results] 1) The TPN-treated group showed significantly lower ulcer index level than the non-treated group. 2) The both groups did not show any difference in histochemical observation. 3) TPN-treated group showed higher level in PAS and AB positive substances, and hexiosamine than the other group. 4) Serum gastrin and pepsinogen levels did not vary between the two groups. 5) The TPN-treated group showed significantly higher tissue uric acid level than the other.
In conclusion, even when tissue metabolism is accelerated, energy supplied is consumed for the metabolism. The above findings show that the generative cell zone in the gastric mucosa is activated by the TPN administration. The TPN solution, an energy source, contains glucose, amino acid, proteins and others. As a result, the gastric mucosal mucoids level rises, which strengthens the defensive mucas-mucosal barrier. This prevents the gastric muosa from stress ulceration. Less

Report

(4 results)
  • 1989 Annual Research Report   Final Research Report Summary
  • 1988 Annual Research Report
  • 1987 Annual Research Report
  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 堀訓也: "ラット水浸拘束潰瘍に対する高カロリ-輸液の効果" 東京慈恵会医科大学雑誌. 103(1). 347-366 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 佐々木龍司: "実験的ストレス潰瘍の成因としての胃組織中尿酸値の変化" 東京慈恵会医科大学雑誌. 103(3). 703-715 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 久保宏隆: "水浸拘束ストレス潰瘍におけるラット胃組織中尿酸値の変動" Cyto-protection & biology. 6. 425-434 (1988)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 青木照明: "MOFの栄養管理ーストレス潰瘍の栄養管理" 最新医学. 44(11). 2302-2307 (1989)

    • Description
      「研究成果報告書概要(和文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Noriya Hori: "An Experimental Study on the Effect of Intravenous Hyperalimentation on Rat Stress Ulcer Induced by Restraint of Water-Immersion" Tokyo Jikeikai Medical Journal 103 : 347-366 (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Ryuji Sasaki: "Alteration in the Gastric Tissue Uric Acid Level as Etiologic Factor of Experimental Stress Ulcer" -ditto- : 703-715 (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Hirotaka Kubo: "Variation of Uric Acid Value in Gastro Tissue of Rat on Stress Ulcer Induced by Restraint of Water-Immersion" Cyto-Protection & Biology 6 : 425-434 (1988).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] Teruaki Aoki, Hirotaka Kubo, Yasuhiro Tabata.: "Nutritional Management of Acute Stress Ulcers Under Multiple Organ Failure" The Sai Shin-Igaku 44 : 2302-2307 (1989).

    • Description
      「研究成果報告書概要(欧文)」より
    • Related Report
      1989 Final Research Report Summary
  • [Publications] 堀訓也: "ラット水侵拘束潰瘍に対する高カロリ-輸液の効果" 東京慈恵会医科大学報誌. 102. 347-366 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 佐々木龍司: "実験的ストレス潰瘍の成因としての胃組織内尿酸値の変化" 東京慈恵会医科大学報誌. 103. 703-715 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 久保宏隆: "水侵拘束ラット潰瘍におけるラット胃組織中尿酸値の変動" Cyto-protection&biology. 6. 425-434 (1988)

    • Related Report
      1989 Annual Research Report
  • [Publications] 青木照明: "MOFの栄養管理-ストレス潰瘍の栄養管理" 最新医学. 44・11. 2302-2307 (1989)

    • Related Report
      1989 Annual Research Report
  • [Publications] 堀訓也: 東京慈恵会医科大学雑誌. 103. 347-366 (1988)

    • Related Report
      1988 Annual Research Report
  • [Publications] 堀 訓也: 東京慈恵会医科大学雑誌. 103. 347-366 (1988)

    • Related Report
      1987 Annual Research Report

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Published: 1987-04-01   Modified: 2016-04-21  

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