Project/Area Number |
62570804
|
Research Category |
Grant-in-Aid for General Scientific Research (C)
|
Allocation Type | Single-year Grants |
Research Field |
Ophthalmology
|
Research Institution | Kawasaki Medical School |
Principal Investigator |
FUJIWARA Hisako Kawasaki Medical School, Department of Ophthalmology, associate professor, 眼科, 助教授 (30033278)
|
Co-Investigator(Kenkyū-buntansha) |
KATAYAMA Toshio Kawasaki Medical School, Department of Ophthalmology, lecturer, 眼科, 講師 (10185811)
EGI Kuniaki Kawasaki Medical School, Department of Ophthalmology, lecturer, 眼科, 講師
石 幸雄 川崎医科大学, 眼科, 講師
|
Project Period (FY) |
1987 – 1989
|
Project Status |
Completed (Fiscal Year 1989)
|
Budget Amount *help |
¥2,500,000 (Direct Cost: ¥2,500,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥600,000 (Direct Cost: ¥600,000)
Fiscal Year 1987: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
Keywords | Allergic ocular inflammation / Chemical mediator / Prostaglandin / Leukotriene B_4 / P A F / Interleukin / Oxygen radical / 眼炎症 / PAF / PAF拮抗剤 / PG合成阻害剤 / プロスタグランジンE_2 / 神経ペプタイド / ベーチェット病 |
Research Abstract |
1. The trend and clinical significance of chemical mediators in the uveitis patients Leukotriene B_4 level was increased in the serum of patients with Behcet's disease. PAF level was also increased in the serum of uveitis patient. These explain increase of chemotaxis activity and high sensitivity of neutrophils from Behcet patients. 2. Inter action of chemical mediators Studying the effects of various mediators on PGE_2 release from albino rabbit iris, Substance P and PAF increased, but VIP inhibited. Interleukin I (IL-1) induced ocular inflammation in rabbit, especially in anterion segment of the eye. The combination of PG synthesis inhibitor and PAF antagonist is most effective to IL-1 induced inflammation. PAF increased superoxide production in human blood and PAF antagonist inhibits its reaction.
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