| Project/Area Number |
63042012
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| Research Category |
Grant-in-Aid for Overseas Scientific Survey.
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| Allocation Type | Single-year Grants |
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| Section | Special Cancer Research |
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| Research Institution | Fukuoka University |
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Principal Investigator |
SHIGEMATSU Takao School of Medicine, Fukuoka University, 医学部, 教授 (60078756)
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| Co-Investigator(Kenkyū-buntansha) |
金 勇一 ソウル大学, 医科大学, 教授
金 丁竜 ソウル大学, 医科大学, 教授
安 允玉 ソウル大学, 医科大学, 助教授
神代 正道 久留米大学, 医学部, 教授 (90080580)
HIYAMA Tomohiko Research Institute, Center for Adult Diseases, Osaka, 調査部, 主幹
AHN Yoon-Ok College of Medicine, Seoul National University
KIM Chung Yong College of Medicine, Seoul National University
MASAMICHI Kojiro School of Medicine, Kurume University
KIM Yong Il College of Medicine, Seoul National University
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| Project Period (FY) |
1988 – 1989
|
| Project Status |
Completed (Fiscal Year 1989)
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| Budget Amount *help |
¥12,000,000 (Direct Cost: ¥12,000,000)
Fiscal Year 1989: ¥6,000,000 (Direct Cost: ¥6,000,000)
Fiscal Year 1988: ¥6,000,000 (Direct Cost: ¥6,000,000)
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| Keywords | Liver Cancer / Hepatitis B Virus / Alcohol / Smoking / Koreans in Japan / Korea / Pathology / Epidemiology |
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| Research Abstract |
Incidence rates of liver cancer in both males and females were nearly 2-fold higher in Korea than in Japan. Female Koreans in Japan appear to sustain the high risk of this disease in their home country. But male Koreans in Japan have much higher a risk of liver cancer than expected from the rate in Korea. Because prevalence of HBs-Ag positives is higher among Koreans in both Japan and Korea than among Japanese, the increased risk of liver cancer among Koreans living in Japan could be partly attributed to HBV infection, particulary with female Koreans.
Resutls of case-control studies on male Koreans in Japan and Korea indicate that HBV infection is a predominant factor in the causation of liver cancer among men in Korea while alcohol drinking is more important in the development of this cancer in male Koreans living in Japan.
Pathological studies based on surgically removed specimens showed no remarkable difference in the histology of hepatocellular carcinoma between Koreans and Japaneses, but the majority of patients with hepatocellular carcinoma in Korea were HBs-Ag positive.
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