| Project/Area Number |
63440029
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| Research Category |
Grant-in-Aid for General Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | University of Tokyo |
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Principal Investigator |
WADA Osamu Univ. of Tokyo, Dept. of Hyg., Professor, 医学部・医学科, 教授 (60009933)
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| Co-Investigator(Kenkyū-buntansha) |
KANAI Yoshikatsu Univ. of Tokyo, Dept. of Hyg., Research Associate, 医学部・医学科, 助手 (60204533)
NAGAHASHI Masaru Univ. of Tokyo, Dept. of Hyg., Research Associate, 医学部・医学科, 助手 (90009994)
真鍋 重夫 東京大学, 医学部(医), 助教授 (90165928)
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥14,100,000 (Direct Cost: ¥14,100,000)
Fiscal Year 1990: ¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1989: ¥3,700,000 (Direct Cost: ¥3,700,000)
Fiscal Year 1988: ¥8,400,000 (Direct Cost: ¥8,400,000)
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| Keywords | Carcinogen / Mutagen / Heterocyclic amine / Exposure level |
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| Research Abstract |
During the last decade, a new series of heterocyclic amines has been isolated in pyrolysates of proteins and amino acids as potens mutagens and later shown to be potent carcinogens in animals. Although the metabolism of these carcinogens has been investigated by some investigators, there has been no information about the exposure levels and metabolism of these compounds in humans. In this investigation, we have clearly demonstrated the followings :
(1) Humans are actually exposed to carcinogenic heterocyclic amines and these carcinogens are present in human plasma, red blood cells and organs such as liver and kidney.
(2) Humans can metabolize these carcinogens, and excretory pathways are via urine and bile in humans.
(3) Carcinogenic heterocyclic amines are widely distributed in such components of the environment as cooked foods, cigarette smoke and airborne particles.
(4) The carcinogens covalently bound to hemoglobin is very suitable for monitoring long-term exposure levels.
(5) Among carcinogenic heterocyclic amines, carcinogenic tryptophan pyrolysis products have unique characteristics : Convulsant activities and potent inhibitory effects on platelet function and dopamine metabolism.
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