| Project/Area Number |
63570787
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
MAEDA Hirotaka (1990) Kyushu University, Faculty of Medicine, Research Associate, 医学部, 助手 (20199631)
下川 浩 (1988-1989) 九州大学, 医学部, 講師 (30128037)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Kazuhiro Kyushu University, Faculty of Medicine, Research Associate, 医学部, 助手 (30221261)
MIYAMOTO Shingo Kyushu University, Medical Institute of Bioregulation, Research Associate, 生体防御医学研究所, 助手 (40209945)
前田 博敬 九州大学, 医学部, 助手 (20199631)
小野山 佳道 九州大学, 医学部, 助手 (00160929)
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| Project Period (FY) |
1988 – 1990
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| Project Status |
Completed (Fiscal Year 1990)
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| Budget Amount *help |
¥2,000,000 (Direct Cost: ¥2,000,000)
Fiscal Year 1990: ¥300,000 (Direct Cost: ¥300,000)
Fiscal Year 1989: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 1988: ¥1,300,000 (Direct Cost: ¥1,300,000)
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| Keywords | Preeclampsia / Microcirculation / Blood flow / Blood viscosity / Venous tone / Thermal conductivity / Endotheline / Endogenous factor / 妊娠 / 細静脈 / 血管内皮細胞傷害 / 静脈壁伸展性 / 心房性ナトリウム利尿ペプタイド |
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| Research Abstract |
From viewpoint of understanding the pathophysiology of preeclampsia, we attempted to assess the factors pertaining to change in tissue microcirculation.
In normal pregnancy, the following findings were obtained : 1) The increases in the number of venules and aggregation of blood flow in conjunctiva bulbi were noted with advance in gestation under conditions of the Intra Vital Video Microscopic System (IVVMS) observation, 2) the values of whole blood viscosity tended to decrease in the second trimester of pregnancy, 3) the peripheral venous tone was found to decrease in the third trimester of pregnancy. These findings suggest that the maternal circulation can adjust itself by controlling the microcirculation, in accord with the increase of bloo volume during normal course of pregnancy.
With regard to preeclamptic pregnancy, the findings were summarized as follows : 1) The decrease in thermal conductivity and disturbed vasodilatation was evident when studied after cooling in the skin and subcutaneous tissues, by means of the equipment measuring deep body temperature distribution, 2) The decrease in the number of venules and the increase of sludge of blood flow measured using IVVMS were observed, 3) the increase in the value of whole blood viscosity together with increase in the peripheral venous tone were noted when compared with those in normal pregnancy. These findings indicate that the disturbance in the tissue microcirculation and the disturbance of both vasodilatation and venodilatation were the determinant factors characterizing the pathophysiological changes in preeclamptic women.
From the study on cell-biology, it was found that there exist the endogeneous factors in the serum of preeclamptic women, thereby making strong cytotoxic effect on endothelial cells.
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