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A population genetic study of subsistence and cultural/behavioral styles of Hill tribes in Thailand

Publicly Offered Research

Project AreaCultural history of PaleoAsia -Integrative research on the formative processes of modern human cultures in Asia
Project/Area Number 17H05132
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Humanities and Social Sciences
Research InstitutionKitasato University

Principal Investigator

太田 博樹  北里大学, 医学部, 准教授 (40401228)

Project Period (FY) 2017-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2018: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2017: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordssex-biased migration / 少数民族 / 古人骨 / ゲノム網羅的SNP解析 / 古人骨DNA / 古代ゲノム / 集団遺伝学 / 文化・行動様式 / mtDNA / Y染色体 / 狩猟採集民 / 農耕民 / タイ少数民族 / sex-biased admixture
Outline of Annual Research Achievements

【研究の目的】出アフリカ以降、現生人類は5~7 万年という短かい期間で、世界各地の様々な環境に適応しながら拡散したので、その環境適応は生業形態や文化・行動様式の変化がゲノムの変化より先行した。今回の研究計画では東南アジアの少数民族および古人骨のゲノム解析を実施することにより、生業形態および文化・行動様式が常染色体を含めたゲノムに与える影響を明らかにする。
【研究計画の実施状況】①東南アジア出土古人骨(25検体)と愛知県渥美半島・伊川津貝塚遺跡出土古人骨(IK002)のゲノム配列にもとづく比較解析を行った。その結果、ホアビニアン文化をもっていた東南アジア出土古人骨とIK002の間で高い近縁性が示された。②現在タイ王国に住んでいる焼畑農耕を行っている山岳民族5民族6集団[アカ族、リス族(メイホンソン県)、リス族(チェンライ県)(以上、夫方居住);カヤー族(赤カレン)、カレン族(白カレン)、ラフ族(以上、妻方居住)]に加え、狩猟採取を行っている2民族(ムラブリ、マニ)の計7民族8集団192人について、白血球由来のDNAを用い、Infinium Global Screening Array(Illumina社)によって、約60万SNPのタイピングを行い、集団遺伝学的解析を行った。その結果、焼き畑農耕民は狩猟採集民よりは有効集団サイズ(Ne)が大きいものの、大規模農耕を行う集団や都市部の人々よりNeが小さい傾向が示された。③アゼルバイジャンから出土したホモ・サピエンスの骨試料からのDNA抽出し、次世代シークエンサー(NGS)ライブラリーを作製、イルミナ社MiSeqでシークエンスを行った。その結果、mtDNAハプログループはIと推定された。

Research Progress Status

平成30年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

平成30年度が最終年度であるため、記入しない。

Report

(2 results)
  • 2018 Annual Research Report
  • 2017 Annual Research Report
  • Research Products

    (17 results)

All 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (12 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results)

  • [Int'l Joint Research] コペンハーゲン大学(デンマーク)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] The prehistoric peopling of Southeast Asia2018

    • Author(s)
      Hugh McColl, Fernando Racimo, Lasse Vinner, Fabrice Demeter, Takashi Gakuhari, …, Hajime Ishida, … Eske Willerslev
    • Journal Title

      Science

      Volume: 361(6397) Issue: 6397 Pages: 88-92

    • DOI

      10.1126/science.aat3628

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A new targeted capture method using bacterial artificial chromosome (BAC) libraries as baits for sequencing relatively large genes2018

    • Author(s)
      Kae Koganebuchi, Takashi Gakuhari, Hirohiko Takeshima, Kimitoshi Sato, Kiyotaka Fujii, Toshihiro Kumabe, Satoshi Kasagi, Takehiro Sato, Atsushi Tajima, Hiroki Shibata, Motoyuki Ogawa, Hiroki Oota
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 7 Pages: 1-14

    • DOI

      10.1371/journal.pone.0200170

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Medaka Population Genome Structure and Demographic History Described via Genotyping-by-Sequencing2018

    • Author(s)
      Katsumura Takafumi、Oda Shoji、Mitani Hiroshi、Oota Hiroki
    • Journal Title

      G3: GENES, GENOMES, GENETICS

      Volume: 9 Issue: 1 Pages: 217-228

    • DOI

      10.1534/g3.118.200779

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ゲノムデータから人類史を読み解く方法ー何がわかって何はわからないかー2017

    • Author(s)
      太田博樹
    • Journal Title

      西洋史研究

      Volume: 新輯第46号 Pages: 105-120

    • Related Report
      2017 Annual Research Report
  • [Presentation] The Jomon genome and migration of anatomical modern humans to East Asia2019

    • Author(s)
      H. Oota
    • Organizer
      Transeurasian millets and beans, language and genes
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 遺伝人類学からみた東アジア・日本列島への人類の拡散2018

    • Author(s)
      太田博樹
    • Organizer
      日本旧石器学会第16回大会シンポジウム「日本列島への人類拡散と後期旧石器時代の成立を考える」
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] A new targeted-capture method using bacteria artificial chromosome (BAC) as baits exclusively developed for sequencing relatively large loci of ancient DNA2018

    • Author(s)
      K. Koganebuchi, T. Gakuhari, H. Takeshima, S. Kasagi, T. Sato, A. Tajima, H. Shibata, M. Ogawa, H. Oota
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The Transition to Farming in Eneolithic (Copper Age) Ukraine was Largely Driven by Population Replacement2018

    • Author(s)
      R.W. Schmidt, D. Fernandes, J. Karsten, T. Harper, G. Madden, S. Ledogar, M. Sokhatsky, H. Oota, R. Pinhasi
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Yonda, H. Ishida, Y. Yamada, H. Shibata, S. Nakagome, E. Willerslev, H. Oota Whole genome analysis of the Jomon remain reveals deep lineage of East Eurasian populations2018

    • Author(s)
      T. Gakuhari, M. Sikora, S. Rasmussen, M. Allentoft, T. Sato, T. Kornrliussen, M. Yonda, H. Ishida, Y. Yamada, H. Shibata, S. Nakagome, E. Willerslev, H. Oota
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Complex human histories of Northeast Asia revealed by correlaions between genes, language, and music2018

    • Author(s)
      H. Matsumae, P.E. Savage, B. Bickel, T.E. Currie, T. Sato, A. Tajima, M. Stoneking, K.K. Shimizu, M. Gillan, S. Brown, H. Oota
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Human population history in the southwestern coastal region of Sea of Okhotsk, inferred from ancient genome analysis2018

    • Author(s)
      T. Sato, N. Adachi, R. Kimura, M. Yoneda, H. Oota, A. Tajima, A. Toyoda, H. Matsumae, K. Koganebuchi, K.K. Shimizu, T. Hanihara, A. Weber, H. Kato, H. Ishida
    • Organizer
      The Society for Molecular Biology and Evolution, Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Is it sex-biased migration/admixture or social selection in population genetic structure in East Asians?2017

    • Author(s)
      H. Oota
    • Organizer
      "Culture History of PaleoAsia" International workshop (organized by B02) Theortical Models of Cultural Evolution during Modern Human Dispersals
    • Related Report
      2017 Annual Research Report
  • [Presentation] タイ少数民族と古人骨を対象とした生業形態とゲノム多様性に関する研究2017

    • Author(s)
      太田博樹、石田貴文
    • Organizer
      第3回パレオアジア文化史研究大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] A trend in recent ancient genome research2017

    • Author(s)
      H. Oota
    • Organizer
      パレオアジア B02 第4回班会議@明治大学中野キャンパス
    • Related Report
      2017 Annual Research Report
  • [Presentation] 東アジア人類集団の遺伝的多様性に与えた影響について2017

    • Author(s)
      太田博樹、石田貴文
    • Organizer
      第4回研究大会パレオアジア文化史学
    • Related Report
      2017 Annual Research Report
  • [Presentation] アジア旧石器時代人類の形質、遺伝子にみられる地理的変異2017

    • Author(s)
      澤藤りかい、木村亮介、太田博樹、石田肇
    • Organizer
      第4回研究大会パレオアジア文化史学
    • Related Report
      2017 Annual Research Report

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Published: 2017-04-28   Modified: 2019-12-27  

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