Comprehensive understanding of neo-self generation, function, and structure

2021 Fiscal Year Final Research Report

• Project Area: Creation, function and structure of neo-self
• Project/Area Number: 16H06495
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokushima
• Principal Investigator: MATSUMOTO Mitsuru 徳島大学, 先端酵素学研究所, 教授 (60221595)
• Co-Investigator(Kenkyū-buntansha): 横須賀 忠 東京医科大学, 医学部, 主任教授 (10359599)
• Project Period (FY): 2016-06-30 – 2021-03-31
• Keywords: ネオ・セルフ / 免疫学的自己 / 総括班

Outline of Final Research Achievements

The general team strengthened the research cooperation of the group members, and the international activity support group worked on training young researchers and building an international network through overseas dispatch. The open recruitment group was attended by 19 (first phase) and 20 (second phase) members, including proposals from different fields that would lead to the elucidation of neo-self from different perspectives. Worked on the functional elucidation of the self-generation/recognition mechanism (Research Item A01). In addition, researchers who propose the latest technology for elucidating the structure of neo-self participated in research item A02 (2 people: 1st stage and 3 people: 2nd stage), and the diversity of open recruitment team members in immunology. It contributed to the activation of research not only in academic fields but also in medical science in general.

Free Research Field

免疫学・内科学

Academic Significance and Societal Importance of the Research Achievements

総括班では、計画班開始年度のキックオフシンポジウム、定期の研究進捗状況の総括のための班員全員参加の全体班会議を計4回開催した。また、計画班員による計画班運営を適切に行うため、アドバイザー、文部科学省学術調査官も交えて助言を仰ぎながら総括班会議を計9回開催した。同様に、総括班の役割としての若手研究者の育成を目的に、若手の会を計3回開催した。また、国内研究者へのネオ・セルフの発信のためにニュースレターを合計4号発刊した。さらに国内外に向けたアウトリーチ活動、日本語／英語の領域ホームページ作成などの広報活動にも積極的に取り組み、その学術的・社会的意義は十分に大きなものであったと考える。