Biosynthetic machinery: Deciphering and regulating the system for creating structural diversity of baioactive metabolites

2014 Fiscal Year Final Research Report

• Project Area: Biosynthetic machinery: Deciphering and regulating the system for bioactive metabolite diversification
• Project/Area Number: 22108001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Hokkaido University
• Principal Investigator: OIKAWA Hideaki 北海道大学, 理学(系)研究科(研究院), 教授 (00185175)
• Co-Investigator(Renkei-kenkyūsha): EGUCHI Tadashi 東京工業大学, 大学院理工学研究科, 教授 (60201365) ; ABE Ikuro 東京大学, 大学院薬学研究科, 教授 (40305496) ; KUZUYAMA Tomohisa 東京大学, 生物生産工学研究センター, 准教授 (30280952) ; DAIRI Tohru 北海道大学, 大学院工学研究科, 教授 (70264679) ; IKEDA Haruo 北里大学, 感染制御科学府, 教授 (90159632) ; GOMI Katsuya 東北大学, 大学院農学研究科, 教授 (60302197) ; SAITO Kazuki 千葉大学, 大学院薬学研究科, 教授 (00146705) ; KANAYA Shigehiko 奈良先端科学技術大学院大学, 情報科学研究科, 教授 (90224584) ; ISHIKAWA Jun 国立感染症研究所, 生物活性物質部, 室長 (40202957)
• Project Period (FY): 2010-04-01 – 2016-03-31
• Keywords: 生合成 / 物質生産 / 二次代謝産物 / 抗生物質 / 抗腫瘍性物質 / バイオインフォマティクス / メタボローム / ゲノム

Outline of Final Research Achievements

To facilitate reconstitution of the biosynthetic machinery consisting of representative skeletal construction enzymes and widespread modification enzymes, organizing team encouraged collaboration of three individual groups, effective presentation of research results to public, and incubation of young researchers in various way. These included development of database for examining biosynthetic pathway of target product, and Web tool for identify target biosynthetic gene clusters from draft genome data; transferring useful expression systems; supporting organization of domestic and international symposium by young researchers; helping start of collaborative researches in project members.

Free Research Field

生物有機化学