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2011 Fiscal Year Annual Research Report

癌幹細胞を標的とする腫瘍根絶技術の新構築の総括班

Administrative Group

Project AreaDevelopment of Novel Treatment Strategies Targeting Cancer Stem Cells
Project/Area Number 22130001
Research InstitutionKyushu University

Principal Investigator

赤司 浩一  九州大学, 医学研究院, 教授 (80380385)

Co-Investigator(Kenkyū-buntansha) 中山 敬一  九州大学, 生体防御医学研究所, 教授 (80291508)
須田 年生  慶応義塾大学, 医学部, 教授 (60118453)
北林 一生  国立がん研究センター, 研究所, 副所長 (20261175)
佐谷 秀行  慶応義塾大学, 医学部, 教授 (80264282)
田賀 哲也  東京医科歯科大学, 難治疾患研究所, 教授 (40192629)
Keywords癌幹細胞 / 幹細胞ニッチ / 分子標的治療
Research Abstract

総括班では、各計画研究および公募研究の有機的連携を促すためのハブ機能を重視して、領域全体の方向性確認を目的としたミーティングの開催を行った。また、webページを通した情報発信に積極的に取り組んだ。
平成23年度の主な取り組みとしては、(1)領域ホームページの充実と研究成果の取りまとめおよびweb公開、(2)第3回総括班会議の開催(9月10日、福岡)、(3)領域内で共有可能な資源の構築などである。
総括班会議では、8題の計画研究と新たに加わった13題の公募研究を含むすべての研究課題について進捗状況を評価し、領域全体における位置づけと他の計画研究との連携可能性について検討を重ねた。
共有可能な資源の具体例としては、(1)各班員が保有する様々なマイクロアレイデータを東京大学医科学研究所 後藤典子准教授の教室で一元管理・解析し、領域横断的に利用可能な包括的データベースを構築すること、(2)マウス異種移植モデルをもちいた研究に不可欠な高度免疫不全マウスとして、九州大学で開発した新規BRGSマウスを班員に提供することで、共通のプラットホームをもちいた互換性の高い移植データを共有可能にすること、(3)タンパク質量分析および修飾解析については、国立がん研究センター研究所 北林一生先生の教室で集中的に解析を行うことで、データの質と汎用性を担保することなどである。
このような取り組みを通して、領域全体としての質および効率の向上が計られたと考えられ、今後益々の成果が期待できる。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

領域内の有機的連携を促すためのハブ機能として、実践的な提案を行うことができていると評価できる。

Strategy for Future Research Activity

上記の取り組みに加えて、領域内で共有可能な様々なデータを一元管理・データベース化する試みをより一層推進する必要がある。

  • Research Products

    (73 results)

All 2012 2011 Other

All Journal Article (42 results) (of which Peer Reviewed: 41 results) Presentation (23 results) Book (4 results) Remarks (4 results)

  • [Journal Article] Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin2012

    • Author(s)
      Bargagna-Mohan P, et al
    • Journal Title

      J.Biol.Chem

      Volume: 287 Pages: 989-1006

    • Peer Reviewed
  • [Journal Article] Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-beta-catenin signaling pathway2012

    • Author(s)
      Nishiyama M, et al
    • Journal Title

      Mol.Cell.Biol

      Volume: 32 Pages: 501-512

    • Peer Reviewed
  • [Journal Article] Proteome-wide identification of uUbiquitylation sites by conjugation of engineered lysine-less ubiquitin2012

    • Author(s)
      Oshikawa K, et al
    • Journal Title

      J.Proteome Res

      Volume: 11 Pages: 796-807

    • Peer Reviewed
  • [Journal Article] Genetic reevaluation of the role of F-box proteins in cyclin D1 degradation2012

    • Author(s)
      Kanie T, et al
    • Journal Title

      Mol.Cell.Biol

      Volume: 32 Pages: 590-605

    • Peer Reviewed
  • [Journal Article] The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, Herceptin sensitivity and tumorigenesis2012

    • Author(s)
      Chan C.-H, et al
    • Journal Title

      Cell

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] odulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012

    • Author(s)
      Tamada M, et al
    • Journal Title

      Cancer Research

      Volume: 72 Pages: 1438-1448

    • Peer Reviewed
  • [Journal Article] Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma2012

    • Author(s)
      Shimizu T, et al
    • Journal Title

      Molecular Cancer Research

      Volume: 10 Pages: 454-468

    • Peer Reviewed
  • [Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor2012

    • Author(s)
      Sugihara E, et al
    • Journal Title

      Oncogene

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] CD45 low c-Kit high cells have hematopoietic properties in the mouse aorta-gonad-mesonephros region2012

    • Author(s)
      Ikuo Nobuhisa
    • Journal Title

      Experimental Cell Research

      Volume: 318 Pages: 705-715

    • DOI

      10.1016/j.yexcr.2012.01.017

    • Peer Reviewed
  • [Journal Article] Self-renewing hematopoietic stem cell is the primary target in pathogenesis ofhuman chronic lymphocytic leukemia. Cancer Cell2011

    • Author(s)
      Kikushige Y, et al
    • Journal Title

      Cancer Cell

      Volume: 20-2 Pages: 246-259

    • Peer Reviewed
  • [Journal Article] The Wnt agonist R-spondin1 regulates systemic graft-versus-host disease by protecting intestinal stem cells2011

    • Author(s)
      Takashima S, et al
    • Journal Title

      J Exp Med

      Volume: 208-2 Pages: 285-294

    • Peer Reviewed
  • [Journal Article] Regenerating islet-derived 3-alpha is a biomarker ofgastrointestinal graft-versus-host disease2011

    • Author(s)
      Ferrara L, et al
    • Journal Title

      Blood

      Volume: 118-25 Pages: 6702-6708

    • Peer Reviewed
  • [Journal Article] The classification of mRNA expression levels by the phosphorylation state of RNAPII CTD based on a combined genome-wide approach2011

    • Author(s)
      Odawara J, et al
    • Journal Title

      BMC Genomics

      Volume: 12 Pages: 516

    • Peer Reviewed
  • [Journal Article] Different risk factors related to adenovirus- or BK virus-associated hemorrhagic cystitis following allogeneic stem cell transplantation2011

    • Author(s)
      Mori Y, et al
    • Journal Title

      Biol Blood Marrow Transplant

      Volume: 18-3 Pages: 458-465

    • Peer Reviewed
  • [Journal Article] Clonal origin of Epstein-Barr virus (EBV)-infected T/NK-cell subpopulations in EBV-positive T/NK-cell lymphoproliferative disorders of childhood2011

    • Author(s)
      Ohga S, et al
    • Journal Title

      J Clin Virol

      Volume: 51-1 Pages: 31-37

    • Peer Reviewed
  • [Journal Article] Role of autotransplantation in the treatment of acute promyelocytic leukemia patients in remission : Fukuoka BMT Group observations and a literature review2011

    • Author(s)
      Kamimura T, et al
    • Journal Title

      Bone Marrow Transplant

      Volume: 46-6 Pages: 820-826

    • Peer Reviewed
  • [Journal Article] miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27kip1, KPC1, and SOCS-12011

    • Author(s)
      Lu, C., Huang, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 4293-4303

    • Peer Reviewed
  • [Journal Article] Fbxw7-dependent degradation of Notch is required for control of "stemness" and neuronal-glial differentiation in neural stem cells2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      J.Biol.Chem

      Volume: 286 Pages: 13754-13764

    • Peer Reviewed
  • [Journal Article] Fbxw7beta resides in the endoplasmic reticulum membrane and protects cells from oxidative stress2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      Cancer Sci

      Volume: 102 Pages: 749-755

    • Peer Reviewed
  • [Journal Article] Proteome of ubiquitin/MVB pathway : possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation2011

    • Author(s)
      Tachiyama R, et al
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 448-466

    • Peer Reviewed
  • [Journal Article] Functional analyses of the activation loop of phototropin2 in Arabidopsis2011

    • Author(s)
      Inoue S, et al
    • Journal Title

      Plant Physiol

      Volume: 156 Pages: 117-128

    • Peer Reviewed
  • [Journal Article] Impaired ovarian development and reduced fertility in female mice deficient in Skp22011

    • Author(s)
      Fotovati A, et al
    • Journal Title

      J.Anat

      Volume: 218 Pages: 668-677

    • Peer Reviewed
  • [Journal Article] Regulation of APC/C(Cdc20) activity by RASSF1A-APC/C(Cdc20) circuitry2011

    • Author(s)
      Chow C, et al
    • Journal Title

      Oncogene

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] Four mood stabilizers commonly induce FEZ1 expression in human astrocytes2011

    • Author(s)
      Yu Z, et al
    • Journal Title

      Bipolar Disord

      Volume: 13 Pages: 486-499

    • Peer Reviewed
  • [Journal Article] p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cellquiescence through interactions with Hsc702011

    • Author(s)
      Zou P, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 247-261

    • Peer Reviewed
  • [Journal Article] p57 is required for quiescence and maintenance of adult hematopoietic stem cells2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 262-271

    • Peer Reviewed
  • [Journal Article] The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo2011

    • Author(s)
      Moroishi T, et al
    • Journal Title

      Cell Metab

      Volume: 14 Pages: 339-351

    • Peer Reviewed
  • [Journal Article] Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice2011

    • Author(s)
      Matsumoto A, et al
    • Journal Title

      Mol.Cell.Biol

      Volume: 31 Pages: 4176-4192

    • Peer Reviewed
  • [Journal Article] TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells2011

    • Author(s)
      Okumura F, et al
    • Journal Title

      Biochim.Biophys.Acta

      Volume: 1813 Pages: 1784-1792

    • Peer Reviewed
  • [Journal Article] Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism2011

    • Author(s)
      Fuster J.J, et al
    • Journal Title

      Arterioscler.Thromb.Vasc.Biol

      Volume: 31 Pages: 2455-2463

    • Peer Reviewed
  • [Journal Article] Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation2011

    • Author(s)
      Matsuzaki F, et al
    • Journal Title

      Mol.Biol.Cell

      Volume: 22 Pages: 4602-4620

    • Peer Reviewed
  • [Journal Article] The SKP2 E3 Ligase regulates basal homeostasis and stress-induced regeneration of hematopoietic stem cells2011

    • Author(s)
      Rodriguez S, et al
    • Journal Title

      Blood

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] The pathophysiological role of the PKCdelta pathway in the intervertebral disc : In vitro, ex vivo and in vivo studies2011

    • Author(s)
      Ellman M.B, et al
    • Journal Title

      Arthritis Rheuma

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] Rodriguez-Puebla, M.L. : Skp2 is necessary for Myc-induced keratinocyte proliferation but dispensable for Myc oncogenic activity in the oral epithelium2011

    • Author(s)
      Sistrunk h, et al
    • Journal Title

      Am.J.Pathol

      Volume: (印刷中)

    • Peer Reviewed
  • [Journal Article] Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere independent mechanism2011

    • Author(s)
      Nitta E, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 4169-4180

    • DOI

      10.1182/blood-2010-08-297390

    • Peer Reviewed
  • [Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero2011

    • Author(s)
      Kubota Y, et al
    • Journal Title

      J Exp Med

      Volume: 208 Pages: 949-960

    • DOI

      10.1084/jem.20102187

    • Peer Reviewed
  • [Journal Article] Bone marrow-derived cells serve : as pro-angiogenic macrophages but not endothelial cells in wound healing2011

    • Author(s)
      Okuno Y, et al
    • Journal Title

      Blood

      Volume: 117 Pages: 5264-5272

    • DOI

      1182/blood-2011-01-330720

    • Peer Reviewed
  • [Journal Article] p57^<Kip2> and p27^<Kip1> cooperate to maintain hematopoietic stem cell quiescence through interaction with Hsc702011

    • Author(s)
      Zou P, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 247-261

    • DOI

      10.1016/j.stem.2011.07.003

    • Peer Reviewed
  • [Journal Article] Osteoclasts are dispensable for haemotopoietic stem cell maintenance an dmobilization2011

    • Author(s)
      Miyamoto K, et al
    • Journal Title

      J Exp Med

      Volume: 208 Pages: 2175-2181

    • DOI

      10.1084/jem.20101890

    • Peer Reviewed
  • [Journal Article] Metabolic regulation of hematopoietic stem cells in the hypoxic niche2011

    • Author(s)
      Suda T, et al
    • Journal Title

      Cell Stem Cell

      Volume: 9 Pages: 298-310

    • DOI

      10.1016/j.stem.2011.09.010

    • Peer Reviewed
  • [Journal Article] Identification of a yolk sac cell population with hematopoietic activity in view of CD45/c-Kit expression2011

    • Author(s)
      Shoutarou Yamasaki
    • Journal Title

      Development Growth & Differentiation

      Volume: 53 Pages: 870-877

    • DOI

      10.1111/j.1440-169X.2011.01293.x

    • Peer Reviewed
  • [Journal Article] アストロサイトの発生・分化2011

    • Author(s)
      鹿川哲史
    • Journal Title

      Clinical Neuroscience

      Volume: 29 Pages: 1239-1242

  • [Presentation] Hematopoietic stem cell metabolism2012

    • Author(s)
      Suda T
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The life of a Stem Cell : From Birth to Death
    • Place of Presentation
      Olympic Valley, USA(招待講演)
    • Year and Date
      2012-03-14
  • [Presentation] Maintenance of immature phenotype of the hematopoietic cell clusters in the aorta-gonad-mesonephros region by SoxF family proteins2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Year and Date
      20111213-20111216
  • [Presentation] SoxF family proteins have roles in maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉県
    • Year and Date
      20111127-20111129
  • [Presentation] External cues and intrinsic properties regulating neural stem cell fate2011

    • Author(s)
      Tetsuya Taga
    • Organizer
      KEY Forum in Developmental Biology and Regenerative Medicine
    • Place of Presentation
      Kumamoto(招待講演)
    • Year and Date
      20110908-20110909
  • [Presentation] Role of SoxF family proteins in the maintenance of immature phenotype of hematopoietic progenitors in the aorta-gonad-mesonephros region2011

    • Author(s)
      Ikuo Nobuhisa
    • Organizer
      The 9^<th> Stem Cell Research Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      20110513-20110514
  • [Presentation] The role of cyclin D1 in inhibition of astrocyte differentiation from neural stem/progenitor cells2011

    • Author(s)
      Norihisa Bizen
    • Organizer
      The 9^<th> Stem Cell Research Symposium
    • Place of Presentation
      Tokyo
    • Year and Date
      20110513-20110514
  • [Presentation] Maintenance of C6 glioma side population with stemness by the cellular and synthetic niche2011

    • Author(s)
      Kouichi Tabu
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      神奈川県
    • Year and Date
      2011-12-14
  • [Presentation] Transcription factor regulation in normal and malignant hematopoiesis2011

    • Author(s)
      Koichi Akashi
    • Organizer
      米国血液学会
    • Place of Presentation
      San Diego,米国
    • Year and Date
      2011-12-10
  • [Presentation] 癌幹細胞の自己複製戦略2011

    • Author(s)
      田賀哲也
    • Organizer
      第56回日本人類遺伝学会
    • Place of Presentation
      千葉市(招待講演)
    • Year and Date
      2011-11-11
  • [Presentation] Niche for hematopoietic stem cells in bone marrow2011

    • Author(s)
      Suda T
    • Organizer
      The 2^<nd> Pacific Meeting for Angiogensis and Lymphangiogenesis
    • Place of Presentation
      Jeju, Korea(招待講演)
    • Year and Date
      2011-10-30
  • [Presentation] Glycolytic metabolism of hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      2011 Cold Spring Harbor Asia Conference : Cellular Programs and Reprogramming
    • Place of Presentation
      Suzhou, China(招待講演)
    • Year and Date
      2011-10-26
  • [Presentation] Control of glioma stem cells by the synthetic polymers2011

    • Author(s)
      Kouichi Tabu
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-04
  • [Presentation] Role of CD44 in cancer stem cells and metastasis2011

    • Author(s)
      Saya H
    • Organizer
      8^<th> International Symposium on Minmal Residual Cancer
    • Place of Presentation
      Osaka International Convention Center, Osaka
    • Year and Date
      2011-09-23
  • [Presentation] Origin of leukemic stem cells2011

    • Author(s)
      Koichi Akashi
    • Organizer
      ドイツ造血幹細胞学会
    • Place of Presentation
      Tubingen、ドイツ
    • Year and Date
      2011-09-07
  • [Presentation] The cellular and synthetic niches for C6 glioma stem cells2011

    • Author(s)
      椨康一
    • Organizer
      平成23年度がん若手研究者ワークショップ
    • Place of Presentation
      長野県
    • Year and Date
      2011-09-02
  • [Presentation] Regulation of quiescent hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      ISEH 40^<th> Annual Scientific Meeting
    • Place of Presentation
      Vancouver, Canada(招待講演)
    • Year and Date
      2011-08-27
  • [Presentation] Regulation of quiescent hematopoietic stem cells2011

    • Author(s)
      Suda T
    • Organizer
      Heidelberg-Kyoto Joint Symposium "Crossing Boundaries : Stem Cells, Materials, and Mesoscopic Sciences"
    • Place of Presentation
      Heidelberg, Germany(招待講演)
    • Year and Date
      2011-07-22
  • [Presentation] 神経幹細胞の分化制御シグナル2011

    • Author(s)
      田賀哲也
    • Organizer
      第96回医工学フォーラム
    • Place of Presentation
      京都市(招待講演)
    • Year and Date
      2011-07-22
  • [Presentation] 子宮体癌幹細胞形質獲得機構におけるdbpC/contrinの関与2011

    • Author(s)
      楠木総司
    • Organizer
      第10回日本婦人科がん分子標的研究会学術集会
    • Place of Presentation
      松江市
    • Year and Date
      2011-07-02
  • [Presentation] Leukemic stem cells2011

    • Author(s)
      Koichi Akashi
    • Organizer
      ヨーロッパ血液学会
    • Place of Presentation
      London、英国(招待講演)
    • Year and Date
      2011-06-11
  • [Presentation] Hypoxic niche for hematopoietic stem cells and cancer stem cells2011

    • Author(s)
      Suda T
    • Organizer
      The 52nd Spring Meeting of the Korean Society of Hematology
    • Place of Presentation
      Seoul, Korea(招待講演)
    • Year and Date
      2011-05-27
  • [Presentation] Normal haematopoietic stem cells and the stem cell niche2011

    • Author(s)
      Suda T
    • Organizer
      The 11^<th> International Symposium on Myelodysplastic Syndromes
    • Place of Presentation
      Edinburgh, UK(招待講演)
    • Year and Date
      2011-05-19
  • [Presentation] 幹細胞維持機構の考察による癌の生存戦略解明へのアプローチ2011

    • Author(s)
      田賀哲也
    • Organizer
      第316回情報計算化学生物学会研究講演会
    • Place of Presentation
      東京都(招待講演)
    • Year and Date
      2011-04-18
  • [Book] サイトカインのすべて2012

    • Author(s)
      備前典久、田賀哲也
    • Publisher
      科学評論社(印刷中)
  • [Book] Molecular Targets of CNS Tumors2011

    • Author(s)
      Kouichi Tabu
    • Total Pages
      26
    • Publisher
      InTech
  • [Book] Stem Cells and Cancer Stem Cells : Therapeutic Applications in Disease and Injury2011

    • Author(s)
      Kouichi Tabu
    • Total Pages
      9
    • Publisher
      Springer
  • [Book] ものづくり技術からみる再生医療-細胞研究・創薬・治療-2011

    • Author(s)
      田賀哲也
    • Total Pages
      7
    • Publisher
      シーエムシー出版
  • [Remarks]

    • URL

      http://www.1nai.med.kyushu-u.ac.jp/

  • [Remarks]

    • URL

      http://www.cancer-stem-cell.com/

  • [Remarks]

    • URL

      http://www.genereg.jp/

  • [Remarks]

    • URL

      http://www.tmd.ac.jp/mri/scr/index.html

URL: 

Published: 2013-06-26  

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