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2023 Fiscal Year Annual Research Report

Photon Pair Theranostics

Administrative Group

Project AreaCreation of diagnostic therapy using nuclear-multi-molecular interaction probes with entangled photon pairs
Project/Area Number 22H05021
Research InstitutionThe University of Tokyo

Principal Investigator

島添 健次  東京大学, 大学院工学系研究科(工学部), 准教授 (70589340)

Co-Investigator(Kenkyū-buntansha) 富田 英生  名古屋大学, 工学研究科, 准教授 (20432239)
佐藤 健  東京大学, 大学院工学系研究科(工学部), 准教授 (30507091)
重河 優大  国立研究開発法人理化学研究所, 仁科加速器科学研究センター, 特別研究員 (60845626)
Project Period (FY) 2022-05-20 – 2025-03-31
Keywords光子対診断治療学 / 量子もつれ / 核スピン
Outline of Annual Research Achievements

原子核→生体空間、化学反応→原子核エネルギーの空間エネルギー多階層構造をつなぐ新たな診断技術(量子もつれ光子放出原子核-分子間相互作用プローブ)の確立による革新的光子対診断治療学の創生の研究活動を総括、円滑に運営する。A班の可視化イメージング技術開発、B班の計測による物理的機構の解明、C班の薬剤開発、D班の理論による解明をつなぐために研究会の企画や国際ワークショップの企画、広報活動やデータのやり取りの整備など研究に必要な活動を実施した。円滑な研究活動を継続するために、情報交換、領域会議の場を設定する。加えて学会やアウトリーチ活動を昨年に引き続いて行った。最終的にこれまで得られてきた成果の取りまとめや今後の方向性を議論する場を設けた。また複数の招待講演を実施した。

Current Status of Research Progress
Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

A班の可視化イメージング技術開発、B班の計測による物理的機構の解明、C班の薬剤開発、D班の理論による解明をつなぐために研究会の企画や国際ワークショップの企画、広報活動やデータのやり取りの整備など研究に必要な活動を実施した。円滑な研究活動を継続するために、情報交換、領域会議の場を設定する。加えて学会やアウトリーチ活動を昨年に引き続いて行った。最終的にこれまで得られてきた成果の取りまとめや今後の方向性を議論する場を設けた。

Strategy for Future Research Activity

これまでの活動により、最終的なin vivoでの実験の準備が整ってきた。最終年度は海外からの関連する研究者は専門家を招聘し、得られてきた成果にたいして議論を行う。特にガンマ線の量子もつれに関する議論や核スピンを利用した診断治療学の可能性についてオープンに議論する場を設ける。またより詳細な実験、理論的研究を進めるために、各班の間を埋めるような研究者に声をかけ、本研究領域を拡大した大きな研究コミュニティを形成する。

  • Research Products

    (35 results)

All 2024 2023 Other

All Int'l Joint Research (2 results) Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 6 results) Presentation (10 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] Johannes Gutenberg University Mainz(ドイツ)

    • Country Name
      GERMANY
    • Counterpart Institution
      Johannes Gutenberg University Mainz
  • [Int'l Joint Research] Brookhaven National Laboratory(米国)

    • Country Name
      U.S.A.
    • Counterpart Institution
      Brookhaven National Laboratory
  • [Journal Article] pH dependence of perturbed angular correlation in DOTA chelated $$^{111}$$In measured with ring-shape gamma-ray detectors2024

    • Author(s)
      Shimazoe Kenji、Donghwan Kim、Mineo Tomoko、Sato Takeshi、Ohta Seiichi、Tatsumi Toshifumi、Sugiyama Akira、Yamatsugu Kenzo、Nomura Sachiyo、Terabayashi Ryohei、Tomita Hideki、Sonoda Tetsu、Shigekawa Yudai、Yokokita Takuya、Uenomachi Mizuki
    • Journal Title

      Interactions

      Volume: 245 Pages: -

    • DOI

      10.1007/s10751-024-01864-7

    • Peer Reviewed / Open Access
  • [Journal Article] Modality for estimating NMR relaxation time using perturbed angular correlation in double-photon emission nuclides2024

    • Author(s)
      Matsumoto Wataru、Feng Boyu、Tamai Yoshiki、Ueki Taisei、Kamada Kei、Uenomachi Mizuki、Tomita Hideki、Fushimi Motofumi、Shimazoe Kenji、Takahashi Hiroyuki、Sekino Masaki
    • Journal Title

      AIP Advances

      Volume: 14 Pages: -

    • DOI

      10.1063/9.0000665

    • Peer Reviewed / Open Access
  • [Journal Article] Implementation of the Time-Dependent Complete-Active-Space Self-Consistent-Field Method for Diatomic Molecules2024

    • Author(s)
      Li Yang、He Feng、Sato Takeshi、Ishikawa Kenichi L.
    • Journal Title

      The Journal of Physical Chemistry A

      Volume: 128 Pages: 1523~1532

    • DOI

      10.1021/acs.jpca.3c06799

    • Peer Reviewed
  • [Journal Article] Time and Energy Resolving Time-over-Threshold ASIC for MPPC module in TOF-PET system (ToT-ASIC2)2023

    • Author(s)
      Orita T.、Uenomachi M.、Shimazoe K.、Ikeda H.
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Pages: P09033~P09033

    • DOI

      10.1088/1748-0221/18/09/p09033

    • Peer Reviewed
  • [Journal Article] Background reduction in PET by double Compton scattering of quantum entangled annihilation photons2023

    • Author(s)
      Kim Donghwan、Rachman Agus Nur、Taisei Ueki、Uenomachi Mizuki、Shimazoe Kenji、Takahashi Hiroyuki
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Pages: P07007~P07007

    • DOI

      10.1088/1748-0221/18/07/P07007

    • Peer Reviewed
  • [Journal Article] Improvement of double photon emission Compton imaging using angular and polarization correlations in cascade photons2023

    • Author(s)
      Kim Donghwan、Ueki Taisei、Rahman Agus Nur、Yan Linlin、Uenomachi Mizuki、Shimazoe Kenji、Takahashi Hiroyuki
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Pages: C05012~C05012

    • DOI

      10.1088/1748-0221/18/05/c05012

    • Peer Reviewed
  • [Journal Article] Simultaneous multi-nuclide imaging via reconstruction-free double-photon emission coincidence imaging method with parallel hole collimator and slat collimator2023

    • Author(s)
      Yan Linlin、Uenomachi Mizuki、Ueki Taisei、Kim Donghwan、Shimazoe Kenji、Takahashi Hiroyuki、Kamada Kei、Shigekawa Yudai、Nambu Akihiro、Yin Xiaojie、Wang Yang、Haba Hiromitsu
    • Journal Title

      Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

      Volume: 1053 Pages: 168305~168305

    • DOI

      10.1016/j.nima.2023.168305

    • Peer Reviewed
  • [Journal Article] Measurement of angular correlation changes in double-photon emission nuclides using ultrasound irradiation2023

    • Author(s)
      Sensui F.、Uenomachi M.、Shimazoe K.、Takahashi H.、Zhihong Z.、Ishijima A.、Nakagawa K.
    • Journal Title

      Journal of Instrumentation

      Volume: 18 Pages: C04001~C04001

    • DOI

      10.1088/1748-0221/18/04/c04001

    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant Cadherin11 expression predicts distant metastasis of gastric cancer2023

    • Author(s)
      Mita Hideaki、Katoh Hiroto、Komura Daisuke、Kakiuchi Miwako、Abe Hiroyuki、Rokutan Hirofumi、Yagi Koichi、Nomura Sachiyo、Ushiku Tetsuo、Seto Yasuyuki、Ishikawa Shumpei
    • Journal Title

      Pathology - Research and Practice

      Volume: 242 Pages: 154294~154294

    • DOI

      10.1016/j.prp.2022.154294

    • Peer Reviewed
  • [Journal Article] Multiancestry genomic and transcriptomic analysis of gastric cancer2023

    • Author(s)
      Totoki Y、Saito-Adachi M、Shiraishi Y、Komura D、Nakamura H、Suzuki A、Tatsuno K、Rokutan H、Hama N、Yamamoto S、Ono H、Arai Y、Hosoda F、Katoh H、Chiba K、Iida N、Nagae G、Ueda H、Shihang C、Sekine S、Abe H、Nomura S、et al.
    • Journal Title

      Nature Genetics

      Volume: 55 Pages: 581~594

    • DOI

      10.1038/s41588-023-01333-x

    • Peer Reviewed / Open Access
  • [Journal Article] Diagnostic utility of trefoil factor families for the early detection of lung cancer and their correlation with tissue expression2023

    • Author(s)
      Minegishi Kentaro、Dobashi Yoh、Koyama Teruhide、Ishibashi Yuko、Furuya Miki、Tsubochi Hiroyoshi、Ohmoto Yasukazu、Yasuda Tomohiko、Nomura Sachiyo
    • Journal Title

      Oncology Letters

      Volume: 25 Pages: -

    • DOI

      10.3892/ol.2023.13725

    • Peer Reviewed
  • [Journal Article] Multivalent tyrosine kinase inhibition promotes T cell recruitment to immune-desert gastric cancers by restricting epithelial-mesenchymal transition via tumour-intrinsic IFN-γ signalling2023

    • Author(s)
      Cao Long Long、Lu Heng、Soutto Mohammed、Bhat Nadeem、Chen Zheng、Peng Dunfa、Gomaa Ahmed、Wang Jia Bin、Xie Jian Wei、Li Ping、Zheng Chao Hui、Nomura Sachiyo、Datta Jashodeep、Merchant Nipun、Chen Zhi Bin、Villarino Alejandro、Zaika Alexander、Huang Chang Ming、El-Rifai Wael
    • Journal Title

      Gut

      Volume: 72 Pages: 2038~2050

    • DOI

      10.1136/gutjnl-2022-329134

    • Peer Reviewed
  • [Journal Article] Lymphatic flow mapping using near-infrared fluorescence imaging with indocyanine green helps to predict lymph node metastasis intraoperatively in patients with esophageal or esophagogastric junction cancer not treated with neoadjuvant chemotherapy2023

    • Author(s)
      Shiomi Shinichiro、Yagi Koichi、Iwata Ryohei、Yajima Shoh、Okumura Yasuhiro、Aikou Susumu、Yamashita Hiroharu、Nomura Sachiyo、Seto Yasuyuki
    • Journal Title

      Surgical Endoscopy

      Volume: 37 Pages: 8214~8226

    • DOI

      10.1007/s00464-023-10368-4

    • Peer Reviewed
  • [Journal Article] Molecular and Immune Profiling of Syngeneic Mouse Models Predict Response to Immune Checkpoint Inhibitors in Gastric Cancer2023

    • Author(s)
      Lee Dagyeong、Choi Junyong、Oh Hye Jeong、Ham In-Hye、Lee Sung Hak、Nomura Sachiyo、Han Sang-Uk、Hur Hoon
    • Journal Title

      Cancer Research and Treatment

      Volume: 55 Pages: 167~178

    • DOI

      10.4143/crt.2022.094

    • Peer Reviewed
  • [Journal Article] <i>YWHAG</i> Deficiency Disrupts the EMT‐Associated Network to Induce Oxidative Cell Death and Prevent Metastasis2023

    • Author(s)
      Lee Jeannie Xue Ting、Tan Wei Ren、Low Zun Siong、Lee Jia Qi、Chua Damien、Yeo Wisely Duan Chi、See Benedict、Vos Marcus Ivan Gerard、Yasuda Tomohiko、Nomura Sachiyo、Cheng Hong Sheng、Tan Nguan Soon
    • Journal Title

      Advanced Science

      Volume: 10 Pages: -

    • DOI

      10.1002/advs.202301714

    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of cancer cell?platelet adhesion as a promising therapeutic target for preventing peritoneal dissemination of gastric cancer2023

    • Author(s)
      Nakayama Takashi、Saito Ryo、Furuya Shinji、Shoda Katsutoshi、Maruyma Suguru、Takiguchi Koichi、Shiraishi Kensuke、Akaike Hidenori、Kawaguchi Yoshihiko、Amemiya Hidetake、Kawaida Hiromichi、Tsukiji Nagaharu、Shirai Toshiaki、Shinmori Hideyuki、Yamamoto Masami、Nomura Sachiyo、et al.
    • Journal Title

      Oncology Letters

      Volume: 26 Pages: -

    • DOI

      10.3892/ol.2023.14125

    • Peer Reviewed
  • [Journal Article] Efficient simulation of multielectron dynamics in molecules under intense laser pulses: implementation of the multiconfiguration time-dependent Hartree?Fock method based on the adaptive finite element method2023

    • Author(s)
      Orimo Yuki、Sato Takeshi、Ishikawa Kenichi L.
    • Journal Title

      Canadian Journal of Chemistry

      Volume: 101 Pages: 664~671

    • DOI

      10.1139/cjc-2022-0280

    • Peer Reviewed
  • [Journal Article] Time-dependent multiconfiguration self-consistent-field and time-dependent optimized coupled-cluster methods for intense laser-driven multielectron dynamics2023

    • Author(s)
      Sato Takeshi、Pathak Himadri、Orimo Yuki、Ishikawa Kenichi L.
    • Journal Title

      Canadian Journal of Chemistry

      Volume: 101 Pages: 698~709

    • DOI

      10.1139/cjc-2022-0297

    • Peer Reviewed
  • [Journal Article] Use of Erfgau Potential for Simulations of Multielectron Dynamics in Intense Laser Pulses2023

    • Author(s)
      Orimo Yuki、Sato Takeshi、Ishikawa Kenichi L.
    • Journal Title

      The Journal of Physical Chemistry A

      Volume: 127 Pages: 10499~10505

    • DOI

      10.1021/acs.jpca.3c06530

    • Peer Reviewed
  • [Journal Article] Production and chemical separation of 229Pa toward observation of γ rays of 229mTh2023

    • Author(s)
      Shigekawa Yudai、Yin Xiaojie、Nambu Akihiro、Wang Yang、Haba Hiromitsu
    • Journal Title

      Journal of Radioanalytical and Nuclear Chemistry

      Volume: 333 Pages: 1479~1486

    • DOI

      10.1007/s10967-023-09069-y

    • Peer Reviewed / Open Access
  • [Presentation] 量子もつれ光子対による原子核ー多分子間相互作用プロープを活用した診断治療学の創生2023

    • Author(s)
      島添 健次、上ノ町 水紀、富田 英生、寺林 稜平、園田 哲、向井 もも、重河 優大、杉山 暁、野村 幸世、横北 卓也、佐藤 健
    • Organizer
      日本科学振興協会 年次大会2023 「会いに行ける科学者フェス」
  • [Presentation] Resonance Ionization Mass Spectroscopy on Americium2023

    • Author(s)
      H. Tomita, F. Weber, K. Wendt
    • Organizer
      Mazurian Lakes Conference on Physics 2023
    • Int'l Joint Research
  • [Presentation] 169Tm(d,2n)169Yb反応による169Ybの製造2023

    • Author(s)
      南部明弘, 重河優大, 殷小杰 臼田祥子, 羽場宏光
    • Organizer
      第60回アイソトープ・放射線研究発表会
  • [Presentation] Antibody Mimetic Drug Conjugate によるがん治療法開発2023

    • Author(s)
      杉山 暁,巽 俊文,金井求,児玉龍彦,田中十志也,川村猛,徳山英利,坂田樹里,山次健三
    • Organizer
      第2回日本抗体学会
  • [Presentation] RADIOIMMUNOTHERAPY OF AT-211-LABELED ANTI-FIBROBLAST GROWTH FACTOR RECEPTOR 4 (FGFR4) ANTIBODY IS A PROMISING TREATMENT FOR PERITONEAL DISSEMINATION OF GASTRIC CANCER: IN IMMUNOCOMPETENT MICE STUDY2023

    • Author(s)
      Komei Kuge, Hiroki Masuda, Wan-Ying Du, Tomohiko Yasuda, Akira Sugiyama, Hiromitsu Haba, Toshifumi Tatsumi, Nobuyoshi Akimitsu, Yoshitaka Kumakura, Hiroshi Yoshida, Yasuyuki Seto, Youichiro Wada, Sachiyo Nomura
    • Organizer
      DDW2023
    • Int'l Joint Research
  • [Presentation] Simulations of intense laser-driven nonadiabatic molecular dynamics using classical and quantum computers2023

    • Author(s)
      Takeshi Sato
    • Organizer
      International Symposium on Ultrafast Intense Laser Science (ISUILS2023),
    • Int'l Joint Research / Invited
  • [Presentation] Molecular Sensing and Imaging through Perturbed Angular Correlation in Nuclear Medicine2023

    • Author(s)
      Kenji Shimazoe
    • Organizer
      HYPERFINE INTERACTION
    • Int'l Joint Research / Invited
  • [Presentation] 放射線を視る。放射線で診る。2023

    • Author(s)
      島添健次
    • Organizer
      第3回SITワークショップ
    • Invited
  • [Presentation] PET検出器におけるデータ取得及び信号処理2023

    • Author(s)
      島添健次
    • Organizer
      日本核医学会PET核医学分科会 PETサマーセミナー2023
    • Invited
  • [Presentation] 光子対を用いた核医学量子イメージングの展開2023

    • Author(s)
      島添健次
    • Organizer
      量子生命科学会第5回大会光量子センシングセッション
    • Invited
  • [Book] 量子生命科学ハンドブック 第5章 医療分野における量子技術2024

    • Author(s)
      島添健次、上ノ町水紀
    • Total Pages
      372
    • Publisher
      (株)エヌ・ティー・エス
    • ISBN
      978-4-86043-882-1
  • [Book] 量子生命科学ハンドブック 光量子による放射性核種分析法の開発2024

    • Author(s)
      富田 英生, 寺林稜平
    • Total Pages
      372
    • Publisher
      NTS
    • ISBN
      978-4860438821
  • [Remarks] 光子対診断治療学ホームページ

    • URL

      photondiagnostic.org

URL: 

Published: 2024-12-25  

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