2015 Fiscal Year Final Research Report
Regulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure
| Project Area | Regulation of polarity signaling during morphogenesis, remodeling, and breakdown of epithelial tubular structure |
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| Project/Area Number |
23112001
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Osaka University |
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Principal Investigator |
Kikuchi Akira 大阪大学, 医学(系)研究科(研究院), 教授 (10204827)
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| Co-Investigator(Renkei-kenkyūsha) |
MINAMI YASUHIRO 神戸大学, 大学院医学研究科, 教授 (70229772)
OHNO SHIGEO 横浜市立大学, 大学院医学系研究科, 教授 (10142027)
SABE HISATAKA 北海道大学, 大学院医学系研究科, 教授 (40187282)
OHTANI HIROKI 島根大学, 医学部, 教授 (20160533)
SUZUKI ATSUSHI 九州大学, 生体防御医学研究所, 教授 (30415195)
OHASHI KAZUMASA 東北大学, 生命科学研究科, 准教授 (10312539)
TAKENAWA TADAOMI 神戸大学, 大学院医学研究科, 特命教授 (40101315)
MIYAJIMA ATSUSHI 東京大学, 分子細胞生物学研究所, 教授 (50135232)
HONDA HISAO 神戸大学, 医学研究科, 客員教授 (10289118)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 上皮菅腔組織形成 / 菅腔生物学 / 国際シンポジウム / 総括班 |
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| Outline of Final Research Achievements |
Epithelial tubular tissues are essential structures of many organs, including lung, gut, kidney, exocrine glands, in multi-cellular organisms. The molecular mechanism underlying the regulation of cellular functions in an individual cell has been so far clarified. In the next decade the understanding of how cells form tissues or organs is one of the important issues in life science field. Moreover, research of diseases from the viewpoint of disruption of epithelial tubular tissues would contribute to solve various problems in medical science field. Therefore, we organized the research group that performs to clarify morphogenesis, remodeling, and breakdown of epithelial tubule structure. This five-year research program succeeded in demonstrating new results for the understanding of tubulogeneis and implication of its abnormality in diseases.
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| Free Research Field |
生化学
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