Chromatin structure, dynamics, and function

2017 Fiscal Year Final Research Report

• Project Area: Dynamic chromatin structure and function
• Project/Area Number: 25116001
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Waseda University
• Principal Investigator: Kurumizaka Hitoshi 早稲田大学, 理工学術院, 教授 (80300870)
• Co-Investigator(Renkei-kenkyūsha): KIMURA Hiroshi 東京工業大学, 科学技術創成研究院細胞制御工学研究センター, 教授 (30241392) ; OBUSE Chikashi 大阪大学, 理学研究科, 教授 (00273855) ; HARAGUCHI Tokuko 情報通信研究機構, 未来ICT研究所, 主任研究員 (20359079) ; YONEDA Yoshihiro 医薬基盤健康栄養研究所, 研究所長 (80191667) ; TOKUNAGA Makio 東京工業大学, 生命理工学院, 教授 (00192659) ; KONO Hidetoshi 量子科学技術研究開発機構, グループリーダー (40291918) ; SAITOH Noriko がん研究会, がん生物部, 部長 (40398235) ; OHKAWA Yasuyuki 九州大学, 生体防御医学研究所, 教授 (80448430) ; HARATA Masahiko 東北大学, 農学研究科, 教授 (70218642)
• Project Period (FY): 2013-06-28 – 2018-03-31
• Keywords: エピジェネティクス / ゲノム機能 / 染色体構築・機能・分配 / ゲノム多様性 / 生体高分子構造・機能ゲノム進化・再編 / 遺伝情報複製・再編 / ゲノム維持修復

Outline of Final Research Achievements

In eukaryotes, genomic DNA is packaged into a nucleus, and forms chromatin, which functions to regulate genomic DNA metabolism. In this research group, we focused to reveal the mechanism, by which the chromatin architecture in the nucleus regulates genomic DNA functions, such as transcription and chromosomal domain formation. The aim of this study is to support the activities of the scientists involved in this research group. To do so, Dr. Kurumizaka and nine adjunctive members organized several international and domestic meetings, and promoted research supports especially for young scientists. Through these activities, we tackled to understand many important aspects of chromatin, and to reveal the mechanism for genomic DNA function in eukaryotes.

Free Research Field

クロマチン、構造生物学