2010 Fiscal Year Final Research Report
Dynamic regulation of metabolite-sensing nuclear receptors
| Project Area | Molecular interaction and modal shift of cellular sensors |
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| Project/Area Number |
18077005
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nihon University |
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Principal Investigator |
MAKISHIMA Makoto Nihon University, 医学部, 教授 (70346146)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Sachiko 日本大学, 医学部, 兼任講師 (10014078)
UNO Shigeyuki 日本大学, 医学部, 講師 (90307851)
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| Research Collaborator |
NISHIDA Shigeru 日本大学, 医学部, 講師 (90211458)
CHOI Mihwa 日本大学, 医学部, 助教 (30571012)
ENDO Kaori 日本大学, 医学部, 専修研究員 (10445744)
ISHIZAWA MICHIYASU 日本大学, 医学研究科, 大学院生
KAWANA Katsuyoshi 大阪大学, 医学系研究科, 大学院生
AMANO Yusuke 日本大学, 歯学研究科, 大学院生
CHO Yoshitake 日本大学, 医学部, ポストドクター (70468742)
OGURA Michitaka 日本大学, 医学研究科, 大学院生
OGEKI Jun 日本大学, 医学研究科, 大学院生
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| Project Period (FY) |
2006 – 2010
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| Keywords | 核内受容体 / 遺伝子 / 蛋白質 / 脂質 / 発現制御 / 代謝 / セルセンサー / モーダルシフト |
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| Research Abstract |
Cellular sensors control body homeostasis by responding to numerous extracellular and intracellular signals. In this study project, we investigated the roles of nuclear receptors that regulate lipid metabolism as sensors for chemical environment and the modal shifts from ligand-receptor interaction to physiological regulation. We elucidated ligand-selective receptor sensing mechanisms and physiological/pharmacological actions, and integration of signaling systems with other cell sensors. The results can be applied to further elucidation of mechanisms of diseases involving nuclear receptors and development of new therapies.
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[Journal Article] Aryl hydrocarbon receptor ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin enhances liver damage in bile duct-ligated mice.2011
Author(s)
Ozeki J, Uno S, Ogura M, Choi M, Maeda T, Sakurai K, Matsuo S, Amano S, Nebert DW, Makishima M.
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Journal Title
Toxicology 280
Pages: 10-17
Peer Reviewed
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