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2022 Fiscal Year Final Research Report

Quantification of physical parameters and construction of theoretical models to understand Chromatin Potential

Planned Research

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Project AreaChromatin potential for gene regulation
Project/Area Number 18H05529
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionNational Institute of Genetics

Principal Investigator

Kimura Akatsuki  国立遺伝学研究所, 遺伝メカニズム研究系, 教授 (10365447)

Co-Investigator(Kenkyū-buntansha) 坂上 貴洋  青山学院大学, 理工学部, 教授 (30512959)
Project Period (FY) 2018-06-29 – 2023-03-31
Keywords細胞核 / クロマチン構造 / ポリマー物理学 / 線虫 / 発生
Outline of Final Research Achievements

In this project, we focused on the mobility of chromatin, which is expected to influence the potential activity of chromatin. We succeeded in formulating the motility of chromatin in the nucleus as a function of the size of the cell nucleus (Phys Rev Lett, 2022). This equation is based on polymer physics. This is an important achievement demonstrating that the behavior of chromatin in living cells can be explained with a polymer physics theory. This result was made possible by a close collaboration with mutual feedback between the physical measurements by the Kimura group, and the construction of the physics theory by the Sakaue group.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

本研究成果の学術的意義は、生きた細胞内でのクロマチンの運動をポリマー物理学の理論で定式化できたことにある。これにより、本研究に用いた線虫初期胚以外の細胞核におけるクロマチンの運動性を予測することが可能となる。今後、この方程式の普遍性を検討し、方程式に従わないクロマチンの運動について集中的に解析することにより運動制御のさらなる理解につながる。また、この方程式を基盤として、クロマチンポテンシャルの他の性質をクロマチンの状態の関数として定式化することにつながると期待できる。

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Published: 2024-01-30  

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