2011 Fiscal Year Final Research Report
| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057003
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
KISHIMOTO Takeo 東京工業大学, 大学院・生命理工学研究科, 教授 (00124222)
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| Co-Investigator(Kenkyū-buntansha) |
CHIBA Kazuyoshi お茶の水女子大学, 理学部, 教授 (70222130)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 細胞周期 / 卵細胞 / 受精 / 細胞死 / Mos-MAPK-Rsk / サイクリン-CDK / カスパーゼ |
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| Research Abstract |
Unfertilized mature eggs are arrested at a particular stage of the cell cycle, and fertilization releases the arrest to initiate embryonic cell cycle. Here we investigated molecular mechanisms underlying this cell cycle arrest and release. We found the dual lock for the arrest and the state of DNA replication machinery, and proposed the arrest mechanism common to metazoan eggs. We further found requirement of protein phosphatases for release of the cell cycle arrest after fertilization.
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Research Products
(20 results)
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[Journal Article] Initiation of DNA replication after fertilization is regulated by p90Rsk at pre-RC/pre-IC transition in starfish eggs2010
Author(s)
Tachibana, K., Mori, M., Matsuhira, T., Karino, T., Inagaki, T., Nagayama, A., Nishiyama, A., Hara, M., and Kishimoto, T.
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Journal Title
Proc. Natl. Acad. Sci. USA
Volume: 107
Pages: 5006-5011
Peer Reviewed
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[Presentation] MI arrest of starfish oocytes2010
Author(s)
Chiba, K.
Organizer
FHL International Symposium "Mechanisms of Egg Maturation and Fertilization: From Sea to Land"
Place of Presentation
Friday Harbor Laboratories, USA
Year and Date
20100910-12
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