2011 Fiscal Year Final Research Report
Positive and negative controls of the cell cycle in early development
| Project Area | Cell Proliferation Control |
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| Project/Area Number |
19057006
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kyushu University |
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Principal Investigator |
SAGATA Noriyuki 九州大学, 大学院・理学研究院, 教授 (80142024)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Tadashi 横浜市立大学, 生命ナノシステム科学研究科, 准教授 (60262309)
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| Project Period (FY) |
2007 – 2011
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| Keywords | ツメガエル / 初期発生 / 細胞分化 / タンパク質 / 細胞周期 |
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| Research Abstract |
In this project, we have studies the detailed mechanisms of both positive and negative controls of the cell cycle during early development of the amphibian Xenopus. We showed that the activity of Emi2, an meiotic inhibitor in unfertilized egg, is finely regulated by both various kinases and phosphatases. Furthermore, we demonstrated that neurogenesis and morphogenesis in early embryos are regulated by various cell-cycle regulators, such as FoxM1, Wee1, Chk1 and Cdc25A. Thus,our results revealed the important roles of various cell cycle regulators in early development of Xenopus.
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