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2010 Fiscal Year Self-evaluation Report

Mechanism of fertilization and epigenomic regulation of germ cells.

Planned Research

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Project AreaThe germline: its developmental cycle and epigenome network
Project/Area Number 20062008
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionOsaka University

Principal Investigator

OKABE Masaru  Osaka University, 微生物病研究所, 教授 (30089875)

Project Period (FY) 2008 – 2012
Keywords生殖細胞 / 遺伝子組換え動物 / 不妊 / 異種キメラ
Research Abstract

生殖系列細胞は、精子と卵子へ分化・成熟し、受精していったん消滅するが、胚から個体へと発生していく過程で新たに誕生する。この新たな生殖系列細胞も生理的、エピジェネティック的に受精能を有し個体として発生できる「機能する配偶子」へと分化していく。本研究では、この連綿と続く生殖系列の世代サイクルを分子生物学的に明らかにするために、受精現象とその前後のエピゲノム調節に焦点を当て、試験管内では再現できない現象について遺伝子操作動物をもちい解き明かす。

  • Research Products

    (11 results)

All 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Formation of a thymus from rat ES cells in xenogeneic nude mouse-rat ES chimeras.2011

    • Author(s)
      Isotani A, Hatayama H, Kaseda K, Ikawa M, Okabe M.
    • Journal Title

      Genes to Cells 16(4)

      Pages: 397-405

    • Peer Reviewed
  • [Journal Article] Calsperin is a testis specific chaperone required for sperm fertility.2011

    • Author(s)
      Ikawa M, Tokuhiro K, Yamaguchi R, Benham AM, Tamura T, Wada I, Satouh Y, Inoue N, Okabe M.
    • Journal Title

      J Biol Chem 18;286(7)

      Pages: 5639-5646

    • Peer Reviewed
  • [Journal Article] From the Cover : Pravastatin induces placental growth factor(PGF)and ameliorates preeclampsia in a mouse model.2011

    • Author(s)
      Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M.
    • Journal Title

      Proc Natl Acad Sci USA 108

      Pages: 1451-1455

    • Peer Reviewed
  • [Journal Article] Identification and disruption of sperm-specific angiotensin converting enzyme-3(ACE3)in mouse.2010

    • Author(s)
      Inoue N, Kasahara T, Ikawa M, Okabe M.
    • Journal Title

      PLoS ONE 5

      Pages: e10301

    • Peer Reviewed
  • [Journal Article] Sperm equatorial segment protein 1, SPESP1, is required for fully fertile sperm in mouse.2010

    • Author(s)
      Fujihara Y, Murakami M, Inoue N, Satouh Y, Kaseda K, Ikawa M, Okabe M.
    • Journal Title

      J Cell Sci. 1;123(Pt 9)

      Pages: 1531-1536

    • Peer Reviewed
  • [Presentation] The Gene-Manipulated Animals and Research in Mechanism of Fertilization2010

    • Author(s)
      Masaru Okabe
    • Organizer
      4th AFLAS Congress Academic Committee
    • Place of Presentation
      台湾台北市Taipei International Convention Center(中華民国)
    • Year and Date
      2010-11-10
  • [Presentation] Fertilization in vivo and Fertilization in vitro2010

    • Author(s)
      Masaru Okabe
    • Organizer
      International Symposium for Immunology of Reproduction joint meeting in conjunction with The 25th Annual Meeting of Japan Society for Immunology of Reproduction
    • Place of Presentation
      大阪府吹田市大阪大学銀杏会
    • Year and Date
      2010-08-29
  • [Presentation] Regulation of sperm migration into the oviduct2010

    • Author(s)
      Masaru Okabe
    • Organizer
      2010 Reproductive Tract Biology Gordon Research Conference
    • Place of Presentation
      Andover,NH Proctor Academy(USA)
    • Year and Date
      2010-08-17
  • [Presentation] 遺伝子改変動物を通して見る精子と卵子の出会い2010

    • Author(s)
      岡部勝
    • Organizer
      第57回日本実験動物学会総会
    • Place of Presentation
      京都市南区京都テルサ(招待講演)
    • Year and Date
      2010-05-13
  • [Presentation] Mechanisms of Fertilization-A View Through Gene Manipulated Mice2010

    • Author(s)
      Masaru Okabe
    • Organizer
      American Society of Andrology ASA 35th AnnualMeeting
    • Place of Presentation
      Houston, TX Omni Houston Hotel(USA)(招待講演)
    • Year and Date
      2010-04-13
  • [Remarks] ホームページ

    • URL

      http://kumikae01.gen-info.osaka-u.ac.jp/tg/greenmouse.cfm

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Published: 2012-03-09   Modified: 2016-04-21  

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