in silico reproduction of physicochemical field of genetic activities

2010 Fiscal Year Self-evaluation Report

• Project Area: The physicochemical field for genetic activities
• Project/Area Number: 20114008
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: National Institute of Genetics
• Principal Investigator: KIMURA Akatsuki National Institute of Genetics, 新分野創造センター, 准教授 (10365447)
• Project Period (FY): 2008 – 2012
• Keywords: シミュレーション / 細胞核 / 染色体 / 線虫

Research Abstract

本研究課題では、空間(場)のパラメータが遺伝情報の収納にどのような影響を及ぼし、細胞周期・個体発生においてどのような役割を果たしているかについてコンピュータシミュレーションを活用して再現・理解することを目指す。線虫C.elegans初期胚をモデル系に用いている。

Research Products

• [Journal Article] A novel mechanism of microtubule length-dependent force to pull centrosomes toward the cell center. (2011)
  • Author(s): Kimura K, Kimura A.
  • Journal Title: BioArchitecture Volume: 1 Pages: 74-79
  • DOI: 10.4161/bioa.1.2.15549
• [Journal Article] Intracellular organelles mediate cytoplasmic pulling force for centrosome centration in the Caenorhabditis elegans early embryo. (2011)
  • Author(s): Kimura K., Kimura A.
  • Journal Title: Proc.Natl.Acad.Sci.USA 108 Pages: 137-142
  • Peer Reviewed
• [Journal Article] Modeling microtubule-mediated forces and centrosome positioning in Caenorhabditis elegans embryos. (2010)
  • Author(s): Kimura A., Onami S.
  • Journal Title: Methods in Cell Biol. 97 Pages: 437-453
  • Peer Reviewed
• [Journal Article] New look inside the spindle : microtubule-dependent microtubule generation within the spindle. (2009)
  • Author(s): Goshima G, Kimura A.
  • Journal Title: Curr.Opin.Cell Biol. 22 Pages: 44-49
  • Peer Reviewed
• [Journal Article] Cell-size-dependent spindle elongation in the Caenorhabditis elegans early embryo. (2009)
  • Author(s): Hara Y, Kimura A.
  • Journal Title: Curr Biol. 19 Pages: 1549-1554
  • Peer Reviewed
• [Presentation] Size-dependency/ independency in the spatial organization of the cell : nuclear positioning and chromosome dynamics in C.elegans embryos. (2011)
  • Author(s): Kimura, A.
  • Organizer: International Symposium Physicochemical Field for Genetic Activities.
  • Place of Presentation: Awaji Yumebutai International Conference Center, Awaji, Japan
  • Year and Date: 2011-01-24
• [Presentation] Quantitative modeling of mitotic spindle in C.elegans embryos. (2010)
  • Author(s): Kimura, A.
  • Organizer: 43rd Annual Meeting for the Japanese Society of Developmental Biologists
  • Place of Presentation: Kyoto
  • Year and Date: 2010-06-22
• [Presentation] Quantitative Measurement and Modeling reveal Cell Size dependent Mechanisms to Elongate Mitotic Spindles in the C.elegans embryo. (2010)
  • Author(s): Kimura, A.
  • Organizer: 2nd Joint Meeting of the French and Japanease Societies for Developmental Biology
  • Place of Presentation: Institut Pasteur, France
  • Year and Date: 2010-05-26
• [Presentation] Force balance models of centrosome centering and apindle elongation in C.elegans embryos. (2010)
  • Author(s): Kimura, A.
  • Organizer: The 101st Boehringer Ingelheim Fonds International Titisee Conferences, Schwarzwaldhotel Titisee
  • Place of Presentation: Germany
  • Year and Date: 2010-03-19
• [Presentation] Construction of cell architecture models focusing on centrosome positioning in C.elegans. (2009)
  • Author(s): Kimura, A.
  • Organizer: Japanese Molecular Biology Pre-meeting Symposium 2009
  • Place of Presentation: Yokohama
  • Year and Date: 2009-12-08
• [Book] Cell Cycle in Development(Kubiak JZ Ed.)(Springer Series - Results and Problems in Cell Differentiation -) (2011)
  • Author(s): Hara Y., Kimura A.
  • Publisher: Cell-size-dependent control of organelle sizes during development. in press
• [Remarks] 国立遺伝学研究所プレスリリース
  • URL: http://www.nig.ac.jp/katudounews/j/09.html
• [Remarks] 国立遺伝学研究所特集記事
  • URL: http://www.nig.ac.jp/tokusyu/intt.html
• [Remarks] 国立遺伝学研究所細胞建築研究室
  • URL: http://www.nig.ac.jp/labs/CelArchi/cell_archi_home.html