2012 Fiscal Year Final Research Report
Studies on function of proteins synthesizing and hydrolyzing ATP
| Project Area | Water plays a key role in ATP hydrolysis and ATP-driven functions of proteins |
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| Project/Area Number |
20118005
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Complex systems
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2012
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| Keywords | ピロリン酸 / エンタルピー / 水分活性 / 極限環境微生物 / ATP |
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| Research Abstract |
This study is aimed at elucidating the molecular mechanism of extremophilic proteins that bind and hydrolyze ATP and its related compounds. Specifically, biochemical and biophysical experimentations have been carried out using ATPase and its related proteins from extremophies living in high salt concentrations and high and low temperatures, which seem to affect on the hydration conditions. In addition, collaborating with theoretical teams, molecular mechanisms for ATP binding and hydrolysis were investigated in the aspects of hydration. As a result, protein mechanisms have been clarified through ATP hydrolyzing proteins from halophiles and thermophiles.
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[Journal Article] Oxidative phosphorylation in a thermophilic, facultative chemoautotroph, Hydrogenophilus thermoluteolus, living prevalently in geothermal niches Environ2013
Author(s)
S. Wakai, M. Masanari, T. Ikeda, N. Yamaguchi, S. Ueshima, K. Watanabe, H. Nishihara, and Y. Sambongi
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Journal Title
Microbiol. Rep
Volume: 5
Pages: 235-242
Peer Reviewed
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