Development of Plasma Processing Technology for Controlling Biological Activity of Fine Particles and Its Medical Application

2013 Fiscal Year Final Research Report

• Project Area: Creation of Science of Plasma Nano-Interface Interactions
• Project/Area Number: 21110010
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering
• Research Institution: Shizuoka University
• Principal Investigator: NAGATSU Masaaki 静岡大学, 創造科学技術大学院, 教授 (20155948)
• Co-Investigator(Kenkyū-buntansha): OGINO Akihisa 静岡大学, 工学研究科, 准教授 (90377721)
• Project Period (FY): 2009-07-23 – 2014-03-31
• Keywords: プラズマ科学 / 表面・界面物性 / ウイルス / バイオテクノロジー

Research Abstract

In the present study, we have carried out the fundamental study on the plasma surface interaction with fine particles having nano-interface for aiming at bio-medical application of nano- and micro-sized particles. The main research results are (1) the clarification of the mechanism for surface modification of nanoparticles by plasma processing and the quantitative evaluation of functional group populations, (2)the development of condensation method of influenza virus using aminated magnetic nanoparticles, (3)the development of plasma surface modification and immobilization of polysaccharide onto ZnO nanophosphors, and so on. The research achievements during the research period are 9 multi-authored books and reports, 57 journal papers, 94 International conference presentation(10 invited talks), and 186 domestic conference presentation(16 invited talks)

Research Products

• [Journal Article] High-efficiency plasma surface modification of graphite-encapsulated magnetic nanoparticles using a pulsed particle explosion technique (2014)
  • Author(s): T.E.Saraswati, S.Tsumura, and M.Nagatsu
  • Journal Title: Jpn. J. Appl. Phys Volume: 53 Pages: 010205
  • Peer Reviewed
• [Journal Article] The Effect of Substrate on the Low-Temperature Carbon Nanomaterials Growth by Microwave Excited Surface-wave Plasma Chemical Vapor Deposition (2013)
  • Author(s): R.V.Bekarevich, S.Miura, A.Ogino, A.V.Rogachev, M.Nagatsu
  • Journal Title: J. Phys. : Conf. Series Volume: 417 Pages: 012042(5)
  • Peer Reviewed
• [Journal Article] RF Plasma-Activated Immobilization of Biomolecules onto Graphite-Encapsulated Magnetic Nanoparticles (2012)
  • Author(s): T.E.Saraswati, A.Ogino, M.Nagatsu
  • Journal Title: Carbon Volume: 50 Pages: 1253-1261
  • Peer Reviewed
• [Journal Article] Mass Spectrometric Study on Inactivation Mechanism of Spore-forming Bacteria by Low-pressure Surface-wave Excited Oxygen Plasma (2011)
  • Author(s): Y.Zhao, A.Ogino, and M.Nagatsu
  • Journal Title: Appl. Phys. Lett Volume: 98 Pages: 191501(3)
  • Peer Reviewed
• [Journal Article] Effects of N_2/O_2 gas mixture ratio on microorganisms inactivation in low-pressure surface wave plasma (2011)
  • Author(s): Y.Zhao, A.Ogino, and M.Nagatsu
  • Journal Title: Jpn. J. Appl. Phys Volume: 50 Pages: 08JF05(5)
  • Peer Reviewed
• [Journal Article] Improvement of UV Emission from Highly Crystalline ZnO Nanoparticles by Pulsed Laser Ablation under O_2/He Glow Discharge (2011)
  • Author(s): Q.Ma, T.E.Saraswati, A.Ogino, M.Nagatsu
  • Journal Title: Appl. Phys. Lett Volume: 98 Pages: 051908
  • Peer Reviewed
• [Journal Article] Amino Group Introduction onto Multiwall Carbon Nanotubes by NH_3/Ar Plasma Treatment (2010)
  • Author(s): C.Chen, D.Lu, B.Liang, A.Ogino, X.Wang, and M.Nagatsu
  • Journal Title: Carbon Volume: 48 Pages: 939-948
  • Peer Reviewed
• [Journal Article] Production of Ultrafine Atmospheric Pressure Plasma Jet with Nano-capillary (2010)
  • Author(s): R.Kakei, A.Ogino, F.Iwata, M.Nagatsu
  • Journal Title: Thin Solid Films Volume: 518 Pages: 3457-3460
  • Peer Reviewed
• [Journal Article] Inactivation Factors of Spore Forming Bactria Using Low-pressure Microwave Plasmas in N_2 and O_2 Gas Mixture (2009)
  • Author(s): M.K.Singh, A.Ogino, M.Nagatsu
  • Journal Title: New J. Phys Volume: 11 Pages: 115027(15)
  • Peer Reviewed
• [Journal Article] Oxygen Functionalization of Multiwall Carbon Nanotubes by Microwave Excited Surface-Wave Plasma Treatment (2009)
  • Author(s): C.Chen, B.Liang, A.Ogino, X.Wang and M.Nagatsu
  • Journal Title: J. Phys. Chem Volume: C113 Pages: 7659-7665
  • Peer Reviewed
• [Presentation] プラズマプロセスによるグラファイト被覆金属ナノ微粒子の表面修飾 (2014)
  • Author(s): 永津 雅章, 楊 恩波, Anchu Viswan , 張晗, 古閑 一憲, 白谷 正治
  • Organizer: 第61回応用物理学会春季学術講演会
  • Place of Presentation: 青山学院大
  • Year and Date: 2014-03-18
  • Invited
• [Presentation] Plasma Surface Functionalization of Nano-sized Materials for Biomedical Application (2014)
  • Author(s): M.Nagatsu
  • Organizer: 6th ISPlasma/7th ICPLANTS
  • Place of Presentation: Meijo University, Nagoya
  • Year and Date: 2014-03-02
  • Invited
• [Presentation] Nano/micro-sized Plasma Surface Modifications for Biomedical Applications (2013)
  • Author(s): M.Nagatsu, M.A.Ciolan, E.Yang, Y.Mochizuki, H.Cho, et al.
  • Organizer: AEPSE 2013
  • Place of Presentation: Jeju, Korea
  • Year and Date: 20130825-30
  • Invited
• [Presentation] Low-Temperature Plasma Processing for Biomedical Applications (2013)
  • Author(s): M.Nagatsu, M.A.Ciolan, et al.
  • Organizer: 19th Symposium on Application of Plasma Processes
  • Place of Presentation: Mala Fatra, Slovakia
  • Year and Date: 20130126-31
  • Invited
• [Presentation] プラズマのバイオ応用における先駆的研究 (2013)
  • Author(s): 永津雅章, 楊恩波, ミハイ チョラン, イウリアナ モトレスク
  • Organizer: 第26回プラズマ材料科学シンポジウム(SPSM26)
  • Place of Presentation: 九大
  • Year and Date: 2013-09-23
  • Invited
• [Presentation] 先進プラズマを用いたバイオプロセスの新展 (2013)
  • Author(s): 永津雅章
  • Organizer: 日本学術振興会第153, 154, 131 委員会合同研究会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2013-06-20
  • Invited
• [Presentation] 低温プラズマプロセスのバイオ・医療応用(プラズマエレクトロニクス賞を受賞して) (2012)
  • Author(s): 永津 雅章,趙 穎,荻野 明久
  • Organizer: 2012年 秋季第73回応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
  • Year and Date: 20120911-14
  • Invited
• [Presentation] Immobilization of Biomolecules onto Magnetic Nanoparticles Functionalized by RF Plasma and Its Medical Application (2012)
  • Author(s): M.Nagatsu, M.Ogata, T.E.Saraswati, K.Kawamura, A.Ogino, and T.Usui
  • Organizer: ICPM-4
  • Place of Presentation: Orleans, France
  • Year and Date: 20120617-21
  • Invited
• [Presentation] Low-Temperature Microwave Plasma Processing of Micro- and Nano-Structured Materials for Bio-Medical Applications (2012)
  • Author(s): M.Nagatsu, R.V.Bekarevich, A.Balmakov, I.Motrescu, A.Ogino, A.Murakawa, M.Ogata and E.Y.Park
  • Organizer: 2012 MRS Spring Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20120409-13
  • Invited
• [Presentation] プラズマ源の開発と医療・バイオ応用への展開 (2011)
  • Author(s): 永津 雅章, 荻野 明久
  • Organizer: プラズマエレクトロニクス分科会20周年記念特別シンポジウム
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-10-22
  • Invited
• [Book] 大気圧プラズマの技術とプロセス開発, 監修:沖野晃俊, 第V 編 医療・バイオ応用, 第1章プラズマ滅菌 (2011)
  • Author(s): 永津雅章 (分担執筆)
  • Publisher: (株) シー・エム・シー出版
• [Book] Sterilization and disinfection by plasma : Sterilization mechanisms, biological and medical applications (Eds. A. Sakudo and H. Shintani) (2010)
  • Author(s): M.Nagatsu (分担執筆)
  • Total Pages: 123-138
  • Publisher: Nova Science Publishers, Inc. New York
• [Book] 大気圧プラズマ―基礎と応用―, 日本学術振興会 プラズマ材料科学第153委員会編, 第3章3.4高周波放電, 第6章6.8.3滅菌 (2009)
  • Author(s): 永津雅章 (分担執筆)
  • Total Pages: 96-113, 381-387
  • Publisher: オーム社
• [Remarks]
  • URL: http://www.eng.shizuoka.ac.jp/~plasma/japan/lab/index.html
• [Remarks] 1. 永津雅章、応用物理学会、「フェロー表彰」受賞(2014.6.5). 受賞(指導学生の受賞も含む、計18件)
• [Remarks] 2. 永津雅章、日本学術振興会 プラズマ材料科学 第153 委員会「第15回プラズマ材料科学賞・基礎部門賞」受賞(2013.8.19). 受賞(指導学生の受賞も含む、計18件)
• [Remarks] 3. 永津雅章、Zhao Ying 、荻野明久、応用物理学会プラズマエレクトロニクス分科会「第10回プラズマエレクトロニクス賞」受賞 (2012.3.15) . 受賞(指導学生の受賞も含む、計18件)
• [Remarks] 4. 永津雅章、財団法人浜松電子工学奨励会「第25回(平成23年度)高柳記念賞」受賞(2011.12.18). 受賞(指導学生の受賞も含む、計18件)
• [Remarks] 5. 永津雅章、荻野明久、平成23年度プラズマ・核融合学会「第16回技術進歩賞」受賞(2011.11.22). 受賞(指導学生の受賞も含む、計18件)
• [Patent(Industrial Property Rights)] 組成物, フィルター, 滅菌方法, 及び菌検出方法 (2011)
  • Inventor(s): 永津 雅章
  • Industrial Property Rights Holder: 静岡大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2011-48219
  • Filing Date: 2011-03-04
• [Patent(Industrial Property Rights)] 荷電粒子ビーム生成装置及び荷電粒子ビーム生成方法 (2011)
  • Inventor(s): 永津 雅章
  • Industrial Property Rights Holder: 静岡大学
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 特願2011-254205
  • Filing Date: 2011-11-21