2013 Fiscal Year Final Research Report
Regulation of cellular community of mouse embryos by cell-cell contacts
| Project Area | Cell Community in early mammalian development |
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| Project/Area Number |
21116003
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Kumamoto University (2010-2013)
The Institute of Physical and Chemical Research (2009) |
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Principal Investigator |
HIROSHI Sasaki 熊本大学, 発生医学研究所, 教授 (10211939)
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| Co-Investigator(Kenkyū-buntansha) |
NISHINAKAMURA Ryuichi 熊本大学, 発生医学研究所, 教授 (70291309)
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| Project Period (FY) |
2009-07-23 – 2014-03-31
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| Keywords | 着床前胚 / Hippoシグナル / 細胞形態 / 細胞間接着 / 細胞分化 / 細胞極性 |
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| Research Abstract |
Cells in early mouse embryos make a community by communicating each other. In this study, we focused on the Hippo signaling pathway and analyzed the roles and underlying mechanisms of cell-cell contacts in regulation of this cellular community, and made following achievements: mechanisms of position-dependent cell fate specification in preimplantation embryos, mechanisms of cell density sensing by a cell, establishment of live imaging system for post-implantation embryos, identification of the importance of the mechanical forces generated by extra-embryonic tissues for notochord morphogenesis, establishment of the systems for analyses of inter-cellular communication in cultured cells and in post-implantation embryos, mechanisms by which Sall4 maintains primordial germ cells, and induction of three-dimensional kidney tissues from stem cells through identification of developmental origin of kidney cells.
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[Journal Article] Polarity-dependent distribution of angiomotin localizes Hippo signaling in preimplantation embryos2013
Author(s)
Hirate Y, Hirahara S, Inoue K-i, Suzuki A, Alarcon VB, Akimoto K, Hirai T, Hara T, Adachi M, Chida K, Ohno S, Marikawa Y, Nakao K, Shimono A, Sasaki H
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Journal Title
Curr. Biol.
Volume: 23
Pages: 1181-1194
Peer Reviewed
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[Journal Article] Cilia at the node of mouse embryos sense fluid flow for left-right determination via Pkd22012
Author(s)
Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H
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Journal Title
Science
Volume: 338
Pages: 226-231
Peer Reviewed
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[Journal Article] Wnt signaling maintains the notochord fate for progenitor cells and supports the posterior extension of the notochord2009
Author(s)
Ukita K, Hirahara S, Oshima N, Imuta Y, Yoshimoto A, Jang C-W, Oginuma M, Saga Y, Behringer RR, Kondoh H, Sasaki H
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Journal Title
Mech. Dev.
Volume: 126
Pages: 791-803
Peer Reviewed
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[Journal Article] Foxa1 and Foxa2 function both upstream of and cooperatively with Lmx1a and Lmx1b in a feedforward loop promoting mesodiencephalic dopaminergic neuron development2009
Author(s)
Lin W, Metzakopian E, Mavromatakis YE, Gao N, Balaskas N, Sasaki H, Briscoe J, Whitsett JA, Goulding M, Kaestner KH, Ang S-L
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Journal Title
Dev. Biol.
Volume: 333
Pages: 386-396
Peer Reviewed
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