2023 Fiscal Year Final Research Report
Theoretical developement of low-entropy reaction space by kinetic analysis of high-speed flow reactions
| Project Area | Highly organized catalytic reaction chemistry realized by low entropy reaction space |
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| Project/Area Number |
21H05080
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (II)
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
正井 宏 東京大学, 大学院総合文化研究科, 助教 (70793149)
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| Project Period (FY) |
2021-08-23 – 2024-03-31
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| Keywords | フロー合成 / 反応速度解析 / フラッシュクエンチフロー法 |
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| Outline of Final Research Achievements |
In conventional methods of reaction rate determination, such as the stopped-flow method, there exists a 'dead time' associated with the time required for the solution to reach the spectrophotometric apparatus and for the stabilization of the spectrophotometric apparatus, making it difficult to accurately calculate the activation entropy change.
In this study, based on the flash chemistry previously investigated by the applicant, we developed a 'flash quench-flow method' to determine the reaction rate by instantaneously stopping the reaction after a predetermined reaction time and calculating the reaction rate from the consumption of reactants and the yield of products. As a result, we achieved reaction rate analysis in extremely fast reactions that complete within a few seconds.
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| Free Research Field |
フロー合成化学
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| Academic Significance and Societal Importance of the Research Achievements |
今回、極めて高速な反応についてその様子を知ることのできる手法を開発した。具体的には数秒以内に完結する反応において、その反応を例えば0.3秒で停止させその途中段階を解析するための手法として「フラッシュクエンチフロー法」を提唱し、その実証を行った。この方法により、これまでは知ることのできなかった高速な反応の速度など様々な知見が得られると期待でき、その知見をもとにさらなるものづくり技術の発展が見込まれる。
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