2023 Fiscal Year Final Research Report
Elucidation of the molecular mechanisms regulating inflammatory memory
| Project Area | Integrated elucidation of inflammatory tissue-resilience and tissue damage-entropy;Creation of innovative science for resolution of inflammation |
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| Project/Area Number |
21H05121
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (III)
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| Research Institution | Chiba University |
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Principal Investigator |
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| Project Period (FY) |
2021-08-23 – 2024-03-31
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| Keywords | 炎症組織記憶 / 組織常在性記憶CD4+ T細胞 / 神経-炎症性組織レジリエンス連関 / iBALT / Proof of concept |
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| Outline of Final Research Achievements |
In order to elucidate the molecular mechanisms of inflammatory memory and to identify 'tissue damage entropy' that increase the risk of relapse or exacerbation of chronic airway inflammatory diseases, we analyzed the inflammatory memory at the single-cell, chromatin and biological levels, as well as in patients. We identified the mechanism of severe disease on viral infection and the mechanism of chronic inflammation pathogenesis associated with increased "tissue damage entropy" via the "neuro-immune interaction".
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| Free Research Field |
免疫学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の大きな成果の一つは、「免疫系」と「神経系」の相互連関によって形成される組織障害エントロピーに関して、その本質を細胞・分子・クロマチンレベルで明らかにしたことである。これは、今後の炎症収束学の創生へつながる学術的意義が大きい成果である。本研究領域の研究を通じてヒトの生体内において炎症記憶の制御機構を解き明かすことは、難治性疾患の病態制御へとつながり、社会貢献上のインパクトも大きい。
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