2023 Fiscal Year Final Research Report
Comprehensive elucidation of multifactorial interactions that establish the transcription unity mechanism
| Project Area | Elucidation of the mechanisms of transcriptional unity by understanding spatiotemporal multifactorial interactions |
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| Project/Area Number |
21H05159
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| Research Category |
Grant-in-Aid for Transformative Research Areas (B)
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| Allocation Type | Single-year Grants |
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| Review Section |
Transformative Research Areas, Section (III)
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
西山 晃 横浜市立大学, 医学部, 准教授 (80589664)
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| Project Period (FY) |
2021-08-23 – 2024-03-31
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| Keywords | 遺伝子発現 / 転写 |
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| Outline of Final Research Achievements |
Our recent studies have suggested that transcription regulation is difficult to understand only by conventional models and that there is a mechanism in which the entire transcription process is unified by multifactorial interactions and regulates gene expression, which we called transcriptional unity mechanism. In this study, we focus on the Mediator complexes that are suggested to play an important role in the multifactor interactions in the transcription unity mechanism, and elucidate the roles of these factors in this mechanism, and clarify the molecular mechanism of the transcription unity.
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| Free Research Field |
分子生物学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は従来の転写研究では着目されてこなかった視点に基づいて転写制御機構を解明するものであり、学術的独自性が高く、未知の転写制御機構が解明されることが強く期待できる。また、最新の知見から、多因子間相互作用による転写ユニティー機構は、DNA修復や複製、細胞周期などの他の核内機能においても機能していることが考えられ、本研究の推進は転写研究と他の核内機能の研究を融合させた新たな研究分野の創造につながることが期待できる。
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