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2014 Fiscal Year Final Research Report

Understanding the neuronal dysfunction/neurocircuit pathology based on iPSC technology

Planned Research

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Project AreaGeneration of synapse-neurocircuit pathology
Project/Area Number 22110007
Research Category

Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKyoto University

Principal Investigator

INOUE Haruhisa  京都大学, iPS細胞研究所, 教授 (70332327)

Co-Investigator(Kenkyū-buntansha) SAKURAI Takashi  順天堂大学, 医学部, 教授 (70225845)
HIOKI Hiroyuki  京都大学, 医学研究科, 助教 (00402850)
EGAWA Naohiro  京都大学, iPS細胞研究所, 特定研究員 (20534340)
KITAOKA Shiho  京都大学, iPS細胞研究所, 特定研究員 (00545246)
Project Period (FY) 2010-04-01 – 2015-03-31
Keywords脳神経疾患 / 脳・神経 / 神経科学
Outline of Final Research Achievements

In this research area, we have developed neuro-imaging, gene-knock-in in human iPSCs, and rapid neuro-differentiation technologies. Using these technologies, we generated and analyzed ALS motor neurons and found novel pathogenesis (Sci Transl Med 2012). Also, we generated cortical neurons and astrocytes from Alzheimer’s patients, and found a new direction of medicine (Cell Stem Cell 2013). Furthermore, we showed the potential of human iPSCs as a cellular resource for ALS transplantation therapy (Stem Cell Reports 2014).
We have promoted collaborative works with other members in this area by sharing our technology.

Free Research Field

幹細胞医学分野

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Published: 2016-06-03  

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