2014 Fiscal Year Final Research Report
Mechanisms that regulate migrating cell dynamics in the developing brain
| Project Area | Cross-talk between moving cells and microenvironment as a basis of emerging order in multicellular systems |
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| Project/Area Number |
22111004
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| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TABATA Hidenori 愛知県心身障害者コロニー発達障害研究所, 神経制御学部, 室長 (80301761)
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| Co-Investigator(Renkei-kenkyūsha) |
TABATA Hidenori 慶應義塾大学, 医学部, 専任講師 (80301761)
ARAMAKI Michihiko 慶應義塾大学, 医学部, 特任助教 (20338099)
NODA Mariko 慶應義塾大学, 医学部, 特任助教 (50571311)
OGAWA Yukino 慶應義塾大学, 医学部, 特任助教 (10624405)
TANAKA Daisuke 慶應義塾大学, 医学部, 特任助教 (90456921)
KANATANI Shigeaki 慶應義塾大学, 医学部, 特任助教 (50424180)
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| Project Period (FY) |
2010-04-01 – 2015-03-31
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| Keywords | 細胞移動 / 大脳皮質 / 発生分化 |
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| Outline of Final Research Achievements |
We have uncovered some novel dynamics and regulatory mechanisms of migrating cells in the developing cerebral cortex. First, we revealed the migratory profiles of inhibitory interneurons and their evolutionary change in the migratory ability. We found that the cellular environment in the neocortical layers II~IV has some features unique to mammals. Secondly, we discovered novel modes of cell migration in the developing cortex. Thirdly, we analyzed the cellular interaction among the moving cortical cells using both mathematical modeling and a cell culture system.
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| Free Research Field |
発生神経生物学
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