Analysis of the interaction between cancer stem cells and their microenvironment.

2014 Fiscal Year Final Research Report

• Project Area: Integrative Research on Cancer Microenvironment Network
• Project/Area Number: 22112004
• Research Category: Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: The University of Tokyo
• Principal Investigator: AIYAMA Tetsu 東京大学, 分子細胞生物学研究所, 教授 (70150745)
• Project Period (FY): 2010-04-01 – 2015-03-31
• Keywords: 微小環境 / がん / がん幹細胞 / 造腫瘍性 / non-coding RNA / hydroxymethyl化

Outline of Final Research Achievements

We have identified and characterized genes involved in the tumorigenicity of glioblastoma and colon cancer cells and obtained the following results:
1) PCDH10, PCDH17, PTPRD, SOX9, LGR5, ALK, Pleiotrophin and TET1 play important roles in the tumorigenicity of glioblastoma cells.2) Endothelial DLL4 induces Notch3-Asef pathway-mediated cell migration.3) TET1-mediated production of 5-hydroxymethylcytosine (5hmC) is required for the tumorigenicity of glioblastoma cells. 5hmC recruites the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates transcription of cancer-related genes.

Free Research Field

がん微小環境