2014 Fiscal Year Final Research Report
Genes/SNPs of lipid mediators and diseases
Project Area | Machineries of bioactive lipids in homeostasis and diseases |
Project/Area Number |
22116010
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Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
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Allocation Type | Single-year Grants |
Review Section |
Biological Sciences
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Research Institution | Kyushu University |
Principal Investigator |
YUTAKA Kiyohara 九州大学, 医学(系)研究科(研究院), 教授 (80161602)
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Co-Investigator(Kenkyū-buntansha) |
KUBO Michiaki 理化学研究所, 総合生命医科学研究センター, 副センター長 (30442958)
NINOMIYA Toshiharu 九州大学, 大学院医学研究院, 教授 (30571765)
HATA Jun 九州大学, 大学院医学研究院, 准教授 (00448432)
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Project Period (FY) |
2010-04-01 – 2015-03-31
|
Keywords | 脂質メディエーター / 遺伝子多型 / エイコサペンタエン酸 / アラキドン酸 / ビタミンD / 心血管病 / 悪性腫瘍 / 慢性腎臓病 |
Outline of Final Research Achievements |
We examined the associations of lipid mediators or their genetic polymorphysms with common diseases in inhabitants of Hisayama Town, Fukuoka. The association study of genetic polymorphisms and common diseases revealed that a polymorphism in PLA2G3 gene was associated with serum HDL cholesterol concentration, and a polymorphism in PA-PLA1 was correlated with body mass index. The cohort study in Hisayama demonstrated that a lower ratio of serum eicosapentaenoic acid to arachidonic acid was a risk factor for the development of coronary heart disease and death from malignant tumors, and that a decreased level of serum 1,25-dihydroxy-vitamin D was associated with an increased risk of chronic kidney disease.
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Free Research Field |
生活習慣病の疫学
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