2014 Fiscal Year Final Research Report
Studies on microenvironment that regulates hematopoietic cells
| Project Area | Molecular mechanisms of cell fate determination in the cells that undergo stepwise differentiation to multiple pathways |
|---|
| Project/Area Number |
22118006
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
|
| Allocation Type | Single-year Grants |
|---|
| Review Section |
Biological Sciences
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
田中 稔 国際医療研究センター, 研究所, 室長 (80321909)
伊藤 暢 東京大学, 分子細胞生物学研究所, 准教授 (50396917)
榎本 豊 東京大学, 分子細胞生物学研究所, 助教 (20608210)
西條 栄子 東京大学, 分子細胞生物学研究所, 技術専門職員 (60376647)
|
|---|
| Project Period (FY) |
2010-04-01 – 2015-03-31
|
| Keywords | 造血 / 免疫 / 肝臓 / 間葉系幹細胞 / サイトカイン |
|---|
| Outline of Final Research Achievements |
The liver is a central organ for homeostasis by playing a major role for metabolism and also a tissue for immune response by holding various immune cells. In fetus, the liver functions as a major hematopoietic tissue, while hematopoieis occurs in the bone marrow in adult. In this study, we studied the environment that supports hematopoiesis in fetal liver and adult bone marrow and showed that the periphery of fetal liver functions as a niche for erythropoiesis and that Oncostatin M plays an important role for bone marrow hematopoiesis by regulating differentiation of bone marrow mesenchymal cells to adipocytes and osteoblasts. We also studied inflammation and regeneration of the liver and showed that M2 macrophages play a role for liver fibrosis induced by injury and that overexpression of IL-4 in the liver induced a novel class of NK cells with strong cytotoxic activity.
|
| Free Research Field |
細胞生物学
|
